4-(9H-fluoren-9-yl)morpholine

Base Information

• Chemical Name: 4-(9H-fluoren-9-yl)morpholine
• CAS No.: 3333-07-1
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.328
• Mol file: 3333-07-1.mol

Synonyms:Morpholine,4-fluoren-9-yl- (6CI,7CI,8CI); NSC 12350

Chemical Property of 4-(9H-fluoren-9-yl)morpholine

Chemical Property:

• Vapor Pressure: 3.32E-06mmHg at 25°C
• Boiling Point: 387.3°C at 760 mmHg
• Flash Point: 114.1°C
• Density: 1.193g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(9H-fluoren-9-yl)morpholine

There total 5 articles about 4-(9H-fluoren-9-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

morpholine (110-91-8,99108-56-2) + N'-((2'-bromo-[1,1’-biphenyl]-2-yl)methylene)-4-methylbenzenesulfonohydrazide → 4-(9H-fluoren-9-yl)morpholine (3333-07-1)

Guidance literature:

With copper acetylacetonate; sodium carbonate; In glycerol; at 80 ℃; for 3h; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1021/cs5014877

Reference yield:

morpholine (110-91-8,99108-56-2) + 9H-fluorene (86-73-7) → 4-(9H-fluoren-9-yl)morpholine (3333-07-1)

Guidance literature:

With di-tert-butyl peroxide; {[Cl₂NNF₆]Cu}2(benzene); In benzene; at 50 ℃; for 20h;

Reference yield:

2′-bromo-[1,1′-biphenyl]-2-carbaldehyde (75295-62-4) → 4-(9H-fluoren-9-yl)morpholine (3333-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 12 h / 80 °C

2: copper acetylacetonate; sodium carbonate / glycerol / 3 h / 80 °C / Sealed tube; Inert atmosphere; Green chemistry

With copper acetylacetonate; sodium carbonate; In ethanol; glycerol;

DOI:10.1021/cs5014877

upstream raw materials:

morpholine

9H-fluoren-9-yl bromide

9H-fluorene

2′-bromo-[1,1′-biphenyl]-2-carbaldehyde