Benzaldehyde, 4-[5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl]-

Base Information

Chemical Name:Benzaldehyde, 4-[5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl]-
CAS No.:569685-42-3
Molecular Formula:C20H11F3N2O2S
Molecular Weight:400.381
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzaldehyde, 4-[5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Benzaldehyde, 4-[5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl]-

There total 8 articles about Benzaldehyde, 4-[5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-1,2,4-oxadiazol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 569685-50-3
3-[(4-hydroxymethyl)phenyl]-5-(4-phenyl-5-trifluoromethyl-2-thienyl)-1,2,4-oxadiazole

: 569685-42-3
3-[(4-formyl)phenyl]-5-(4-phenyl-5-trifluoromethyl-2-thienyl)-1,2,4-oxadiazole

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jm0492507

Reference yield:

: 350-92-5
1,1,1-Trifluoro-3-phenylpropan-2-one

: 569685-42-3
3-[(4-formyl)phenyl]-5-(4-phenyl-5-trifluoromethyl-2-thienyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 82 percent / phosphorus oxychloride / 20 h / 70 °C

2.1: NaH / tetrahydrofuran / 25 °C

2.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

3.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

4.1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / 20 °C

5.1: 423 mg / pyridine / xylene / 1 h / 140 °C

6.1: 89 percent / DIBALH / CH₂Cl₂ / 1 h / -78 °C

7.1: 66 percent / 4-methylmorpholine N-oxide; tetrapropylammonium perruthnate; 4A molecular sieves / acetonitrile / 2 h / 20 °C

With pyridine; sodium hydroxide; tetrapropylammonium perruthennate; oxalyl dichloride; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; xylene;
DOI:10.1021/jm0492507

Reference yield:

: 119197-24-9,119197-25-0,146936-34-7
3-chloro-4,4,4-trifluoro-2-phenyl-but-2-enal

: 569685-42-3
3-[(4-formyl)phenyl]-5-(4-phenyl-5-trifluoromethyl-2-thienyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 25 °C

1.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

3.1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / 20 °C

4.1: 423 mg / pyridine / xylene / 1 h / 140 °C

5.1: 89 percent / DIBALH / CH₂Cl₂ / 1 h / -78 °C

6.1: 66 percent / 4-methylmorpholine N-oxide; tetrapropylammonium perruthnate; 4A molecular sieves / acetonitrile / 2 h / 20 °C

With pyridine; sodium hydroxide; tetrapropylammonium perruthennate; oxalyl dichloride; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; xylene;
DOI:10.1021/jm0492507