569685-50-3Relevant academic research and scientific papers
POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
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Page/Page column 15, (2008/06/13)
Disclosed are polycyclic compounds of formula I which are useful as sphingosine-1 -phosphate (S 1 P) receptor ligands, particularly as immunosuppressants.
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists
Hale, Jeffrey J.,Lynch, Christopher L.,Neway, William,Mills, Sander G.,Hajdu, Richard,Keohane, Carol Ann,Rosenbach, Mark J.,Milligan, James A.,Shei, Gan-Ju,Parent, Stephen A.,Chrebet, Gary,Bergstrom, James,Card, Deborah,Ferrer, Marc,Hodder, Peter,Strulovici, Berta,Rosen, Hugh,Mandala, Suzanne
, p. 6662 - 6665 (2007/10/03)
Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally bioavailable amino acid-based S1P1 agonists represented by 7. Many of the new
