4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde

Base Information

Chemical Name:4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde
CAS No.:569685-43-4
Molecular Formula:C19H13F3O2S
Molecular Weight:362.372
Hs Code.:
DSSTox Substance ID:DTXSID00458168
Wikidata:Q82281334

Synonyms:4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde;569685-43-4;SCHEMBL3821170;DTXSID00458168;4-((4-Phenyl-5 trifluoromethyl-2-thienyl)methoxy)benzaldehyde;4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzaldehyde

Suppliers and Price of 4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde

Chemical Property:

PSA：54.54000
LogP:5.82540
XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:362.05883531
Heavy Atom Count:25
Complexity:429

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(SC(=C2)COC3=CC=C(C=C3)C=O)C(F)(F)F

Technology Process of 4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde

There total 5 articles about 4-((4-Phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 256488-46-7
2-hydroxymethyl-4-phenyl-5-trifluoromethylthiophene

: 569685-43-4
4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzaldehyde

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm0492507

Reference yield:

: 350-92-5
1,1,1-Trifluoro-3-phenylpropan-2-one

: 569685-43-4
4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / phosphorus oxychloride / 20 h / 70 °C

2.1: NaH / tetrahydrofuran / 25 °C

2.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

3.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

4.1: 98 percent / BH₃*THF / tetrahydrofuran / 3 h / Heating

5.1: 60 percent / PPh₃; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With sodium hydroxide; borane-THF; sodium hydride; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0492507

Reference yield:

: 119197-24-9,119197-25-0,146936-34-7
3-chloro-4,4,4-trifluoro-2-phenyl-but-2-enal

: 569685-43-4
4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 25 °C

1.2: 78 percent / tetrahydrofuran / 20 h / 20 °C

2.1: 93 percent / aq. NaOH / ethanol / 0.5 h / 20 °C

3.1: 98 percent / BH₃*THF / tetrahydrofuran / 3 h / Heating

4.1: 60 percent / PPh₃; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With sodium hydroxide; borane-THF; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0492507