2-Benzyloxy-5-methoxy-benzaldehyde

Base Information

• Chemical Name: 2-Benzyloxy-5-methoxy-benzaldehyde
• CAS No.: 56979-57-8
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• DSSTox Substance ID: DTXSID30358142
• Nikkaji Number: J1.017.231D
• Wikidata: Q82138469
• Mol file: 56979-57-8.mol

Synonyms:2-benzyloxy-5-methoxy-benzaldehyde;56979-57-8;5-methoxy-2-phenylmethoxybenzaldehyde;2-Benzyloxy-5-methoxybenzaldehyde;2-(benzyloxy)-5-methoxybenzaldehyde;MFCD00436294;5-methoxy-2-(phenylmethoxy)benzaldehyde;starbld0019364;CBMicro_036196;Cambridge id 6043008;Oprea1_825458;SCHEMBL2573994;DTXSID30358142;5-Methoxy-2-(benzyloxy)benzaldehyde;AKOS008911657;SY313533;BIM-0036450.P001;CS-0196307;E86348;SR-01000225784;A1-05010;SR-01000225784-1

Chemical Property of 2-Benzyloxy-5-methoxy-benzaldehyde

Chemical Property:

• Melting Point: 48 °C
• Boiling Point: 406.9±30.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.154±0.06 g/cm3(Predicted)
• LogP: 3.08670
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 248

Purity/Quality:

99% ^*data from raw suppliers

5-Methoxy-2-phenylmethoxybenzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OCC2=CC=CC=C2)C=O

Technology Process of 2-Benzyloxy-5-methoxy-benzaldehyde

There total 3 articles about 2-Benzyloxy-5-methoxy-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + benzyl bromide (100-39-0) → 2-benzyloxy-5-methoxybenzaldehyde (56979-57-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 60 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2012.10.060

Reference yield: 86.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + benzyl chloride (100-44-7) → 2-benzyloxy-5-methoxybenzaldehyde (56979-57-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 5h;

DOI:10.3390/molecules26103034

Reference yield:

4-methoxy-phenol (150-76-5) → 2-benzyloxy-5-methoxybenzaldehyde (56979-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium methanolate / methanol

2: potassium carbonate / acetonitrile / 80 °C

With potassium carbonate; magnesium methanolate; In methanol; acetonitrile;

DOI:10.1016/j.ejmech.2013.11.035

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

benzyl chloride

benzyl bromide

4-methoxy-phenol

Downstream raw materials:

Ethyl 2-(2-benzyloxy-5-methoxyphenyl)-2-hydroxyacetate

(2-(benzyloxy)-5-methoxyphenyl)methanol

2-Acetoxy-2-(2-benzyloxy-5-methoxyphenyl)acetonitrile

1-Benzyloxy-4-methoxy-2-((E)-2-nitro-vinyl)-benzene

Refernces

• 1、 Huang, Ling,Huang, Yi-You,Huang, Yue,Li, Jinjian,Li, Zhe,Luo, Hai-Bin,Su, Rui,Wu, Yinuo,Yuan, Han,Zhang, Chen,Zhou, Yan. "Design, synthesis, and evaluation of dihydropyranopyrazole derivatives as novel pde2 inhibitors for the treatment of alzheimer’s disease". . . Retrieved 2021/06/03.
• 2、 Demay-Drouhard, Paul,Du, Ke,Samanta, Kushal,Wan, Xintong,Yang, Weiwei,Srinivasan, Rajavel,Sue, Andrew C.-H.,Zuilhof, Han. "Functionalization at Will of Rim-Differentiated Pillar[5]arenes". supporting information. p. 3976 - 3980. Retrieved 2019/05/08.