Boc-leu-met-OH

Base Information

Chemical Name:Boc-leu-met-OH
CAS No.:57092-20-3
Molecular Formula:C16H30N2O5S
Molecular Weight:362.48500
Hs Code.:
DSSTox Substance ID:DTXSID50526321
Nikkaji Number:J245.712A
Wikidata:Q82394682

Synonyms:BOC-LEU-MET-OH;57092-20-3;(2S)-2-[[(2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]-4-methylsulfanylbutanoic acid;(S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanamido)-4-(methylthio)butanoic acid;SCHEMBL7315478;DTXSID50526321;N-(tert-Butoxycarbonyl)-L-leucyl-L-methionine;(S)-2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-4-(methylthio)butanoic acid

Suppliers and Price of Boc-leu-met-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-[N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-LEUCYL]-L-METHIONINE 95.00%
5MG
$ 500.56

Total 7 raw suppliers

Chemical Property of Boc-leu-met-OH

Chemical Property:

Boiling Point:576.1±50.0 °C(Predicted)
PKA:3.33±0.10(Predicted)
PSA：130.03000
Density:1.130±0.06 g/cm3(Predicted)
LogP:3.03010
XLogP3:2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:362.18754324
Heavy Atom Count:24
Complexity:435

Purity/Quality:

HPLC>98% ^*data from raw suppliers

N-[N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-LEUCYL]-L-METHIONINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(CCSC)C(=O)O)NC(=O)OC(C)(C)C
Isomeric SMILES:CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)OC(C)(C)C

Technology Process of Boc-leu-met-OH

There total 1 articles about Boc-leu-met-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2280-69-5
Boc-Leu-Met-OMe

: 57092-20-3
Boc-Leu-Met-OH

Guidance literature:: With sodium hydroxide; In water; acetone; for 1.5h;

Reference yield:

: 57092-20-3
Boc-Leu-Met-OH

: 89083-78-3
cyclo-(-Ala-Phe-Ile-Gly-Leu-Met-)

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide 2) N-methylmorpholine / 1) 1 h, r.t., DMF, 2) 30 min, 0 deg C; 10 h, r.t.

2: 72 percent / N,N'-Dicyclohexylcarbodiimide, DCCI / dimethylformamide / 1.) 2 h, -10 deg C, 2.) 12 h, r.t.

3: 1) CF₃COOH, 2) N-Methylmorpholine / 1) 20 min., r.t., 2) DMF, Pyridin, 36 h, r.t.

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 57092-20-3
Boc-Leu-Met-OH

: [(2S,3S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-propionylamino}-3-phenyl-propionylamino)-3-methyl-pentanoylamino]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide 2) N-methylmorpholine / 1) 1 h, r.t., DMF, 2) 30 min, 0 deg C; 10 h, r.t.

2: HCl, Ethylmethylsulfide / acetic acid / 0.67 h / Ambient temperature

3: triethylamine / dimethylformamide; pyridine / 0.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; Ethyl methyl sulfide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In pyridine; acetic acid; N,N-dimethyl-formamide;