6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one

Base Information

Chemical Name:6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one
CAS No.:571188-81-3
Molecular Formula:C14H16BrN3O2S
Molecular Weight:370.27
Hs Code.:
Mol file:571188-81-3.mol

Synonyms:6-bromo-8-cyclopentyl-2-methansulfinyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one;

Suppliers and Price of 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one
250mg
$ 130.00

Total 32 raw suppliers

Chemical Property of 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one

Chemical Property:

Melting Point:>160oC (dec.)
Boiling Point:542.8±60.0 °C(Predicted)
PKA:-1.69±0.20(Predicted)
PSA：84.06000
Density:1.66±0.1 g/cm3(Predicted)
LogP:3.58060
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 6-Bromo-8-cyclopentyl-5-methyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one is used as a reactant in the preparation of pyrido[2,3-d]pyrimidin-7-one derivatives as selective inhibitors of cyclin-dependent kinases 4 and 6.

Technology Process of 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one

There total 19 articles about 6-BroMo-8-cyclopentyl-2-Methanesulfinyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 362656-25-5
6-bromo-8-cyclopentyl-5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 571188-81-3
6?bromo?8?cyclopentyl?5?methyl?2?(methylsulfinyl)pyrido[2,3?d]pyrimidin?7(8H)?one

Guidance literature:: With 2-benzylsulfonyl-3-phenyloxaziridine; In dichloromethane;
DOI:10.1021/jm049355+

Reference yield: 87.0%

: 362656-23-3
8?cyclopentyl?5?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one

: 571188-81-3
6?bromo?8?cyclopentyl?5?methyl?2?(methylsulfinyl)pyrido[2,3?d]pyrimidin?7(8H)?one

Guidance literature:: With N-Bromosuccinimide; acetic acid; In water; acetonitrile; for 2h;

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 571188-81-3
6?bromo?8?cyclopentyl?5?methyl?2?(methylsulfinyl)pyrido[2,3?d]pyrimidin?7(8H)?one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane

2.1: lithium aluminium tetrahydride / tetrahydrofuran

3.1: manganese(IV) oxide / chloroform

4.1: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere; Cooling with ice

4.2: 22 h / Reflux

5.1: sodium hydride / tetrahydrofuran

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3.5 h / 20 °C

With manganese(IV) oxide; N-Bromosuccinimide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;