Acetic acid, [[(4-methylphenyl)thioxomethyl]thio]-

Base Information

• Chemical Name: Acetic acid, [[(4-methylphenyl)thioxomethyl]thio]-
• CAS No.: 57149-19-6
• Molecular Formula: C10H10O2S2
• Molecular Weight: 226.32
• Mol file: 57149-19-6.mol

Synonyms:2-<4-Methyl-thiobenzoyl-mercapto>-essigsaeure;

Chemical Property of Acetic acid, [[(4-methylphenyl)thioxomethyl]thio]-

Chemical Property:

• PSA: 94.69000
• LogP: 2.48830

Purity/Quality:

{[(4-Methylphenyl)carbonothioyl]thio}acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, [[(4-methylphenyl)thioxomethyl]thio]-

There total 5 articles about Acetic acid, [[(4-methylphenyl)thioxomethyl]thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + chloroacetic acid (79-11-8) + para-methylphenylmagnesium bromide (4294-57-9) → (4-methyl-thiobenzoylsulfanyl)-acetic acid (57149-19-6)

Guidance literature:

Multistep reaction; (i), (ii) /BRN= 605438/, Na₂CO₃;

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + para-bromotoluene (106-38-7) + chloroacetic acid (79-11-8) → (4-methyl-thiobenzoylsulfanyl)-acetic acid (57149-19-6)

Guidance literature:

para-bromotoluene; With magnesium; In diethyl ether;

carbon disulfide; In diethyl ether;

chloroacetic acid; In diethyl ether; Further stages.;

DOI:10.1016/j.bmcl.2007.07.048

Reference yield:

para-methylphenylmagnesium bromide (4294-57-9) → (4-methyl-thiobenzoylsulfanyl)-acetic acid (57149-19-6)

Guidance literature:

With diethyl ether; anschliessend Behandeln mit Eis und Behandeln der erhaltenen wss. Reaktionsloesung mit Natrium-chloracetat;

upstream raw materials:

carbon disulfide

chloroacetic acid

para-methylphenylmagnesium bromide

4-tolylmagnesium chloride

Downstream raw materials:

4-methyl-thiobenzoic acid N-methyl-hydrazide

N,N'-Dimethyl-N-[1-methylsulfanyl-1-p-tolyl-meth-(Z)-ylidene]-hydrazinium; iodide

4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide

5-(4-methylphenyl)-1,2,3,4-thiatriazole

Refernces

• 1、 Bursavich, Matthew G.,Gilbert, Adam M.,Lombardi, Sabrina,Georgiadis, Katy E.,Reifenberg, Erica,Flannery, Carl R.,Morris, Elisabeth A.. "5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2)". . p. 5630 - 5633. Retrieved 2008/03/14.