4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide

Base Information

• Chemical Name: 4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide
• CAS No.: 143538-71-0
• Molecular Formula: C₁₀H₁₄N₂S
• Molecular Weight: 194.301
• Mol file: 143538-71-0.mol

Synonyms:

Chemical Property of 4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide

There total 1 articles about 4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1,2-Dimethylhydrazine (540-73-8) + (4-methyl-thiobenzoylsulfanyl)-acetic acid (57149-19-6) → 4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide (143538-71-0)

Guidance literature:

With sodium hydroxide; In methanol; for 0.5h; 0 deg C to rt;

DOI:10.1055/s-1992-26183

Reference yield:

4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide (143538-71-0) → N'-[1-(N,N'-Dimethyl-hydrazino)-1-p-tolyl-meth-(Z)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 48 h / Ambient temperature

2: methanol / 48 h / Ambient temperature

In methanol; acetonitrile;

DOI:10.1055/s-1992-26183

Reference yield:

4-Methyl-thiobenzoic acid N,N'-dimethyl-hydrazide (143538-71-0) + methyl iodide (74-88-4) → N,N'-Dimethyl-N-[1-methylsulfanyl-1-p-tolyl-meth-(Z)-ylidene]-hydrazinium; iodide (144841-92-9)

Guidance literature:

In acetonitrile; for 48h; Yield given; Ambient temperature;

DOI:10.1055/s-1992-26183

upstream raw materials:

1,2-Dimethylhydrazine

(4-methyl-thiobenzoylsulfanyl)-acetic acid

Downstream raw materials:

N,N'-Dimethyl-N-[1-methylsulfanyl-1-p-tolyl-meth-(Z)-ylidene]-hydrazinium; iodide

Refernces