5-{4-nitrobenzylidene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione

Base Information

• Chemical Name: 5-{4-nitrobenzylidene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
• CAS No.: 57270-89-0
• Molecular Formula: C13H11N3O5
• Molecular Weight: 289.247
• Mol file: 57270-89-0.mol

Synonyms:5-(4-nitrobenzylidene)-N,N'-dimethylbarbituric acid;5-(4'-nitrobenzylidene)-1,3-dimethylbarbituric acid;1,3-dimethyl-5-(4-nitro-benzylidene)-barbituric acid;5-(4-Nitrobenzylidene)-1,3-dimethylbarbituric acid;5-(4'-nitrobenzylidene) 1,3-dimethylbarbituric acid;1,3-dimethyl-5-(4-nitro-benzylidene)-pyrimidine-2,4,6-trione;

Chemical Property of 5-{4-nitrobenzylidene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione

Chemical Property:

• PSA: 103.51000
• LogP: 1.42760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-{4-nitrobenzylidene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione

There total 10 articles about 5-{4-nitrobenzylidene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-dimethylbarbituric acid (769-42-6) + 4-nitrobenzaldehdye (555-16-8) → 5-(4-nitrobenzylidene)-1,3-dimethylbarbituric acid (57270-89-0)

Guidance literature:

In water; at 50 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2017.06.029

Reference yield: 85.0%

6-Amino-1,3-dimethylbarbituric acid (6642-31-5) + 4-nitrobenzaldehdye (555-16-8) → 5-(4-nitrobenzylidene)-1,3-dimethylbarbituric acid (57270-89-0)

Guidance literature:

With iron(III) chloride hexahydrate; water; for 0.75h; Reflux; Green chemistry;

DOI:10.1039/c4ra03413a

Reference yield: 75.0%

1,3-dimethylbarbituric acid (769-42-6) + 4-nitrobenzaldehdye (555-16-8) + triethyl phosphite (122-52-1) → 5-(4-nitrobenzylidene)-1,3-dimethylbarbituric acid (57270-89-0) + diethyl ((1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-yl)(4-nitrophenyl)methyl) phosphonate

Guidance literature:

With multi-walled carbon nanotube-CO-NH(CH₂)₂NH-SO₃H; In dichloromethane; for 24h; Time; Catalytic behavior; Reflux;

DOI:10.1080/10426507.2018.1452230

upstream raw materials:

1,3-dimethylbarbituric acid

4-nitrobenzaldehdye

1,3-dimethyl-5-(4-nitrobenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione

6-Amino-1,3-dimethylbarbituric acid

Downstream raw materials:

C₂₁H₁₈N₄O₅

3-[(1H-indol-3-yl)(4-nitrophenyl)methyl]-1H-indole

bis-(2-methyl-indol-3-yl)-(4-nitro-phenyl)-methane

5-(4-chlorobenzylidene)-1,3-dimethylbarbituric acid