Methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate

Base Information

Chemical Name:Methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate
CAS No.:57355-62-1
Molecular Formula:C14H15NO2
Molecular Weight:229.279
Hs Code.:
DSSTox Substance ID:DTXSID00531122
Nikkaji Number:J807.819J
Wikidata:Q82402734

Synonyms:57355-62-1;Methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate;DTXSID00531122

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:229.110278721
Heavy Atom Count:17
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CN(C=CC1)CC2=CC=CC=C2

Technology Process of Methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate

There total 13 articles about Methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 126225-70-5
1-(2-bromobenzyl)-1,4-dihydro-3-methoxycarbonylpyridine

: 57355-62-1
methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate

: 126225-84-1
rel-(8aS)-6-methoxycarbonyl-1,2,3,7,8,8a-hexahydrobenz--indolizine

: 126225-76-1,126225-77-2
rel-(8S,8aS)-8-methoxycarbonylperhydrobenz indolizine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 3h; Heating;
DOI:10.1016/S0040-4020(01)81101-7

Reference yield: 22.0%

: 126225-70-5
1-(2-bromobenzyl)-1,4-dihydro-3-methoxycarbonylpyridine

: 57355-62-1
methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate

: 126225-84-1
rel-(8aS)-6-methoxycarbonyl-1,2,3,7,8,8a-hexahydrobenz--indolizine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1.5h; Heating;
DOI:10.1016/S0040-4020(01)81101-7

Reference yield:

: 93-60-7
methyl 3-pyridinecarboxylate

: 57355-62-1
methyl 1-benzyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / methanol / 2.5 h / Heating

2: 76 percent / Na₂S₂O₄, Na₂CO₃ / H₂O / 1.) 50 deg C, 20 min, 2.) room temp., 30 min

3: 22 percent / Bu₃SnH, AIBN / benzene / 1.5 h / Heating

With sodium dithionite; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium carbonate; In methanol; water; benzene;
DOI:10.1016/S0040-4020(01)81101-7