4-(4-Methoxy-2,3,6-trimethylphenyl)butan-2-one

Base Information

• Chemical Name: 4-(4-Methoxy-2,3,6-trimethylphenyl)butan-2-one
• CAS No.: 57399-32-3
• Molecular Formula: C14H20O2
• Molecular Weight: 220.312
• DSSTox Substance ID: DTXSID60385446
• Nikkaji Number: J3.512.976F
• Wikidata: Q82178242
• Mol file: 57399-32-3.mol

Synonyms:4-(4-methoxy-2,3,6-trimethylphenyl)butan-2-one;57399-32-3;SCHEMBL11506820;DTXSID60385446;STK370737;AKOS005446347;J3.512.976F;4-(2,3,6-Trimethyl-4-methoxyphenyl)butane-2-one

Chemical Property of 4-(4-Methoxy-2,3,6-trimethylphenyl)butan-2-one

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 220.146329876
• Heavy Atom Count: 16
• Complexity: 237

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1CCC(=O)C)C)C)OC

Technology Process of 4-(4-Methoxy-2,3,6-trimethylphenyl)butan-2-one

There total 13 articles about 4-(4-Methoxy-2,3,6-trimethylphenyl)butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2,5,6-trimethyl-4-methoxyphenyl)-but-1-en-3-one (62924-31-6) → 4-(4-methoxy-2,3,6-trimethylphenyl)butan-2-one (57399-32-3)

Guidance literature:

With hydrogen; nickel; In ethanol; under 760 Torr;

DOI:10.1007/BF02218431

Reference yield:

4-(4'-methoxy-2',3',6'-trimethylphenyl)-but-3-ene-2-one (54757-47-0) → 4-(4-methoxy-2,3,6-trimethylphenyl)butan-2-one (57399-32-3)

Guidance literature:

With hydrogen; nickel;

DOI:10.1021/jm00217a011

Reference yield:

3-(2,5-dimethyl-4-methoxybenzoyl)-2-methylpropanoic acid (154406-43-6) → 4-(4-methoxy-2,3,6-trimethylphenyl)butan-2-one (57399-32-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / H₂ / 10percent Pd/C / acetic acid / 6 h / 2585.7 Torr / Ambient temperature

2: 95 percent / PPA / 1 h / 120 °C

3: 82 percent / DIBAL-H / toluene / 2 h / -78 °C

4: 98 percent / POCl₃ / triethylamine / 1.) RT, 3 h, 2.) reflux, 1 h

5: 1.) NaBH₄, 2.) NaBH₄, 3.) NH₃, 4.) Li, 5.) Jones reagent

With sodium tetrahydroborate; jones reagent; ammonia; hydrogen; lithium; diisobutylaluminium hydride; trichlorophosphate; palladium on activated charcoal; In acetic acid; triethylamine; toluene;

upstream raw materials:

7-methoxy-2,5,8-trimethyl-3,4-dihydronaphthalene

1-(2,5,6-trimethyl-4-methoxyphenyl)-but-1-en-3-one

4-(4'-methoxy-2',3',6'-trimethylphenyl)-but-3-ene-2-one

2,3,5-trimethylanisole

Downstream raw materials:

5-(4-methoxy-2,3,6-trimethylphenyl)-3-methylpent-1-yn-3-ol

1-(2,5,6-trimethyl-4-methoxyphenyl)-but-1-en-3-one

trans-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6-nonatriensaeure

trans-5-(4-Methoxy-2,3,6-trimethylphenyl)-3-methyl-2-pentenal