Ethyl (1-hydroxyethyl)phenylphosphinate

Base Information

• Chemical Name: Ethyl (1-hydroxyethyl)phenylphosphinate
• CAS No.: 57483-33-7
• Molecular Formula: C10H15O3P
• Molecular Weight: 214.201
• DSSTox Substance ID: DTXSID90566226
• Nikkaji Number: J763.252E
• Mol file: 57483-33-7.mol

Synonyms:57483-33-7;Ethyl (1-hydroxyethyl)phenylphosphinate;DTXSID90566226

Chemical Property of Ethyl (1-hydroxyethyl)phenylphosphinate

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.07588133
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOP(=O)(C1=CC=CC=C1)C(C)O

Technology Process of Ethyl (1-hydroxyethyl)phenylphosphinate

There total 2 articles about Ethyl (1-hydroxyethyl)phenylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl Phenylphosphinate (172487-18-2,2511-09-3) + acetaldehyde (75-07-0,9002-91-9) → ethyl 1-hydroxyethane(P-phenyl)phosphinate (57483-33-7)

Guidance literature:

With aluminum oxide; potassium fluoride; Ambient temperature;

DOI:10.1039/p19960002179

Reference yield: 72.0%

ethyl hydrogen phenylphosphonate (4546-19-4) + acetaldehyde (75-07-0,9002-91-9) → ethyl 1-hydroxyethane(P-phenyl)phosphinate (57483-33-7)

Guidance literature:

With triethylamine; at 65 - 70 ℃; for 1h;

Reference yield: 62.0%

ethyl 1-hydroxyethane(P-phenyl)phosphinate (57483-33-7) + butyryl chloride (141-75-3) → ethyl (1-butyryloxyethyl)phenylphosphinate (866612-48-8)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 24h;

upstream raw materials:

ethyl hydrogen phenylphosphonate

acetaldehyde

ethyl Phenylphosphinate

Downstream raw materials:

Ethyl phenyl(1-chloroethyl)phosphinate

(R_P,R)-ethyl (1-hydroxyethyl)phenylphosphinate

ethyl (1-butyryloxyethyl)phenylphosphinate

(1-Amino-ethyl)-phenyl-phosphinic acid ethyl ester

Refernces

• 1、 Majewska,Kafarski,Lejczak. "Lipase-catalysed resolution of 1-hydroxyethane-P-phenylphosphinates". . p. 561 - 566. Retrieved 2007/10/03.
• 2、 Gajda, Tadeusz. "A CONVENIENT SYNTHESIS OF O-ETHYL-1-AMINOALKYLPHOSPHINATES". . p. 59 - 64. Retrieved 2007/10/02.