Phosphinic acid, (1-aminoethyl)phenyl-, ethyl ester

Base Information

Chemical Name:Phosphinic acid, (1-aminoethyl)phenyl-, ethyl ester
CAS No.:117196-74-4
Molecular Formula:C₁₀H₁₆NO₂P
Molecular Weight:213.216
Hs Code.:
DSSTox Substance ID:DTXSID001222627

Synonyms:Phosphinic acid, (1-aminoethyl)phenyl-, ethyl ester;DTXSID001222627;117196-74-4

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Chemical Property of Phosphinic acid, (1-aminoethyl)phenyl-, ethyl ester

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:213.09186575
Heavy Atom Count:14
Complexity:214

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOP(=O)(C1=CC=CC=C1)C(C)N

Technology Process of Phosphinic acid, (1-aminoethyl)phenyl-, ethyl ester

There total 5 articles about Phosphinic acid, (1-aminoethyl)phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117196-66-4
(1-Formylamino-ethyl)-phenyl-phosphinic acid ethyl ester

: 117196-74-4
(1-Amino-ethyl)-phenyl-phosphinic acid ethyl ester

Guidance literature:: With hydrogenchloride; In methanol; for 12h; Ambient temperature;
DOI:10.1055/s-1988-27550

Reference yield:

: 15901-09-4
(α-Amino-ethyl)-phenyl-phosphinsaeure

: 117196-74-4
(1-Amino-ethyl)-phenyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 3 h / Heating

2: HCl / methanol / 12 h / Ambient temperature

With hydrogenchloride; In methanol;
DOI:10.1055/s-1988-27550

Reference yield:

: 4546-19-4
ethyl hydrogen phenylphosphonate

: 117196-74-4
(1-Amino-ethyl)-phenyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / triethylamine / 1 h / 65 - 70 °C

2: diethyl azodicarboxylate, Ph₃P, HN₃ / CH₂Cl₂; benzene / 1.) 0 deg C, 30 min, 2.) RT, 20 h

3: 1.) Ph₃P, 2.) H₂O / 1.) benzene, RT, 2 h, 2.) benzene, from 50 deg C to 55 deg C, 5 h

With tris-(2-chloro-ethyl)-amine; water; triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; benzene;