2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Base Information

Chemical Name:2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
CAS No.:57598-73-9
Molecular Formula:C19H20N2
Molecular Weight:276.381
Hs Code.:
ChEMBL ID:CHEMBL345117
DSSTox Substance ID:DTXSID90504946
Wikidata:Q82359735

Synonyms:2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;57598-73-9;CHEMBL345117;SCHEMBL2362746;DTXSID90504946;WIXKEUGJHJMDEA-UHFFFAOYSA-N

Suppliers and Price of 2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:276.162648646
Heavy Atom Count:21
Complexity:363

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)C4=CC=CC=C4

Technology Process of 2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

There total 7 articles about 2,8-Dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 19686-05-6
2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 57598-73-9
2,8-dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: With potassium phosphate; copper(l) iodide; L-proline; In N,N-dimethyl-formamide; at 150 ℃; for 12h;

Reference yield:

: 73931-18-7
8-Methyl-5-phenyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester

: 57598-73-9
2,8-dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: With aluminium hydride; In tetrahydrofuran; diethyl ether; at 5 - 15 ℃; for 0.5h;
DOI:10.1021/jm00180a011

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 57598-73-9
2,8-dimethyl-5-phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

2: AlH₃ / diethyl ether; tetrahydrofuran / 0.5 h / 5 - 15 °C

With aluminium hydride; sodium carbonate; copper(I) bromide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00180a011