Cyclo[2,2-dimethyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R)-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl](9CI)

Base Information

Chemical Name:Cyclo[2,2-dimethyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R)-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl](9CI)
CAS No.:219660-54-5
Molecular Formula:C30H41 Cl N2 O7
Molecular Weight:577.118
Hs Code.:

Cyclo[2,2-dimethyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R)-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl](9CI)

Synonyms:LY404291

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclo[2,2-dimethyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R)-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl](9CI)

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclo[2,2-dimethyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R)-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl](9CI)

There total 3 articles about Cyclo[2,2-dimethyl-b-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R)-5-hydroxy-6-methyl-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl](9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(3-Amino-2,2-dimethyl-propionyloxy)-4-methyl-pentanoic acid (1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-but-3-enyl ester

: 219660-54-5
(E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-16-((R)-1-methyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With 2-hydroxypyridin; Yield given;
DOI:10.1016/S0040-4039(98)01994-7

Reference yield:

: 168777-81-9
(3S,4R)-1-[(tert-butyldimethylsilyl)oxy]-4-methylhex-5-en-3-ol

: 219660-54-5
(E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-16-((R)-1-methyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: TBAF

2: TFA

3: 2-hydroxypyridine

With 2-hydroxypyridin; tetrabutyl ammonium fluoride; trifluoroacetic acid;
DOI:10.1016/S0040-4039(98)01994-7

Reference yield:

: 219621-70-2
(3S,4R)-4-methylhex-5-ene-1,3-diol

: 219660-54-5
(E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-16-((R)-1-methyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: TFA

2: 2-hydroxypyridine

With 2-hydroxypyridin; trifluoroacetic acid;
DOI:10.1016/S0040-4039(98)01994-7