N-(2-chlorophenyl)furan-2-carboxamide

Base Information

Chemical Name:N-(2-chlorophenyl)furan-2-carboxamide
CAS No.:58050-52-5
Molecular Formula:C11H8ClNO2
Molecular Weight:221.643
Hs Code.:
DSSTox Substance ID:DTXSID70351839
Nikkaji Number:J1.144.553E
Wikidata:Q82128606

Synonyms:N-(2-chlorophenyl)furan-2-carboxamide;58050-52-5;N-(2-chlorophenyl)-2-furamide;CBMicro_029489;Oprea1_005978;Oprea1_067360;SCHEMBL6632751;DTXSID70351839;STK158547;AKOS000675818;BIM-0029439.P001;CS-0322890;Z27812187

Suppliers and Price of N-(2-chlorophenyl)furan-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-chlorophenyl)furan-2-carboxamide

Chemical Property:

PSA：42.24000
LogP:3.25830
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:221.0243562
Heavy Atom Count:15
Complexity:235

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)NC(=O)C2=CC=CO2)Cl

Technology Process of N-(2-chlorophenyl)furan-2-carboxamide

There total 4 articles about N-(2-chlorophenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 95-51-2
o-chloroaniline

: 1026046-13-8
2-furanoyl sulfonate

: 58050-52-5
N-(2-chlorophenyl)furan-2-carboxamide

Guidance literature:: With PEG-400; potassium carbonate; In acetonitrile; for 0.25h; Heating;
DOI:10.1080/00397919908086466

Reference yield: 41.0%

: 527-69-5
2-furancarbonyl chloride

: 95-51-2
o-chloroaniline

: 58050-52-5
N-(2-chlorophenyl)furan-2-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo301805d

Reference yield:

: 88-14-2
2-furanoic acid

: 58050-52-5
N-(2-chlorophenyl)furan-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 0 - 20 °C

2: DIPEA; DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/ja055819x