4-[(4-Chloroanilino)methyl]phenol

Base Information

Chemical Name:4-[(4-Chloroanilino)methyl]phenol
CAS No.:58336-45-1
Molecular Formula:C13H12ClNO
Molecular Weight:233.697
Hs Code.:
European Community (EC) Number:666-203-7
DSSTox Substance ID:DTXSID20401893
Wikidata:Q82205182

Synonyms:58336-45-1;4-(((4-Chlorophenyl)amino)methyl)phenol;4-[(4-chloroanilino)methyl]phenol;Phenol, 4-[[(4-chlorophenyl)amino]methyl]-;SCHEMBL6556042;4-(4-chloroanilinomethyl)phenol;DTXSID20401893;ZDEUJEHDUBUXNW-UHFFFAOYSA-N;AKOS000235234

Suppliers and Price of 4-[(4-Chloroanilino)methyl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-[(4-Chloroanilino)methyl]phenol

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:233.0607417
Heavy Atom Count:16
Complexity:196

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CNC2=CC=C(C=C2)Cl)O

Technology Process of 4-[(4-Chloroanilino)methyl]phenol

There total 4 articles about 4-[(4-Chloroanilino)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-hydroxybenzenediazonium tetrafluoroborate

: 58336-45-1
4-(((4-chlorophenyl)amino)methyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; palladium diacetate / 12 h / 20 °C / Inert atmosphere

2.1: iron(II) chloride / acetonitrile / 8 h / 100 °C / Sealed tube; Inert atmosphere

2.2: 20 °C

With sodium acetate; palladium diacetate; iron(II) chloride; In acetonitrile;
DOI:10.1021/acs.orglett.9b03160

Reference yield:

: 106-47-8
4-chloro-aniline

: 2948-37-0
N-(4-chlorophenyl)benzylamine

: 58336-45-1
4-(((4-chlorophenyl)amino)methyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 10 h / 20 °C / Inert atmosphere

2.1: iron(II) chloride / acetonitrile / 8 h / 100 °C / Sealed tube; Inert atmosphere

2.2: 20 °C

With hydrogenchloride; iron(II) chloride; sodium nitrite; In water; acetonitrile;
DOI:10.1021/acs.orglett.9b03160

Reference yield:

: 3296-05-7
1-azido-4-chlorobenzene

: 6554-98-9
trans-4-Hydroxystilbene

: 2948-37-0
N-(4-chlorophenyl)benzylamine

: 58336-45-1
4-(((4-chlorophenyl)amino)methyl)phenol

Guidance literature:: 1-azido-4-chlorobenzene; trans-4-Hydroxystilbene; With iron(II) chloride; In acetonitrile; at 100 ℃; for 8h; Sealed tube; Inert atmosphere;

With methanol; sodium tetrahydroborate; at 20 ℃;
DOI:10.1021/acs.orglett.9b03160