3296-05-7

Basic information

• Product Name: 1-Azido-4-chlorobenzene solution
• Synonyms: 1-Azido-4-chlorobenzene solution;Benzene, 1-azido-4-chloro-;1-Azido-4-chlorobenzene solution ~0.5 M in tert-butyl methyl ether, >=95.0% (HPLC)
• CAS NO: 3296-05-7
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.56906
• Mol File: 3296-05-7.mol
• Article Data: 134

Chemical Properties

• Melting Point: 20°C
• Boiling Point: 252.42°C (rough estimate)
• Flash Point: -30℃
• Appearance: /
• Density: 1.2634
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: ?20°C
• BRN: 1210408
• CAS DataBase Reference: 1-Azido-4-chlorobenzene solution(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azido-4-chlorobenzene solution(3296-05-7)
• EPA Substance Registry System: 1-Azido-4-chlorobenzene solution(3296-05-7)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-22-38-43
• Safety Statements: 16-36/37
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 3296-05-7(Hazardous Substances Data)

Usage

General Description

1-Azido-4-chlorobenzene solution is a chemical compound that consists of a benzene ring with an azido group and a chlorine substituent. It is commonly used as a reagent in organic synthesis and as a precursor for various pharmaceutical and agrochemical products. The azido group in the compound makes it highly reactive and capable of participating in a variety of chemical reactions, such as azide-alkyne cycloaddition and nucleophilic aromatic substitution. The solution is typically handled under strict safety precautions due to its explosive nature and potential toxicity. Overall, 1-Azido-4-chlorobenzene solution is an important and versatile chemical reagent with a wide range of applications in synthetic chemistry.

InChI:InChI=1/C6H4ClN3/c7-5-1-3-6(4-2-5)9-10-8/h1-4H

Upstream product

• 1073-69-4 N-4-chlorophenylhydrazine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 76867-49-7 9-Chloro-1-(4-chloro-phenyl)-10b-pyrrolidin-1-yl-3a,4,5,10b-tetrahydro-1H-6-thia-1,2,3-triaza-benzo[e]azulene 
• 932-98-9 1-chloro-4-nitroso-benzene 
• 106-39-8 bromochlorobenzene 
• 4648-54-8 trimethylsilylazide 
• 2028-74-2 p-chlorobenzenediazonium chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 108-90-7 chlorobenzene 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 28149-53-3 HBN₄(C₆H₄-4-Cl)2 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 106-47-8 4-chloro-aniline 
• 7664-93-9 sulfuric acid 

Downstream Products

• 122447-41-0 1,3'-bis-(4-chloro-phenyl)-5,5'-bis-(1-hydroxy-cyclohexyl)-1H,3'H-[4,4']bi[1,2,3]triazolyl 
• 138801-87-3 1-(4-chlorophenyl)-4-trimethylsilyl-1H-1,2,3-triazole 
• 104503-35-7 1-(4-Chloro-phenyl)-4,5-bis-methoxymethyl-1H-[1,2,3]triazole 
• 3559-61-3 O,O-Diaethyl-N-<4-chlor-phenyl>-N'-m-tolyl-phosphorsaeure-amidin 
• 3559-78-2 O,O-Diethyl-N-(4-chlor-phenyl)-N'-p-tolyl-phosphorsaeure-amidin 
• 3559-80-6 O,O-Diaethyl-N-<4-chlor-phenyl>-N'-<4-dimethylamino-phenyl>-phosphorsaeure-amidin 
• 5524-79-8 O,O-Diaethyl-N-(4-chlor-phenyl)-N'-(4-methoxy-phenyl)-phosphorsaeure-amidin 
• 139399-68-1 2-Acetamido-5-chlorophenyl acetate 
• 30438-94-9 N,N-diallyl-4-chlorobenzenamine 
• 13519-80-7 N-allyl-4-chloroaniline 
• 35727-05-0 N-(1-[4-chloro-phenyl]-1H-[1,2,3]triazol-4-ylmethyl)-piperidine 
• 35727-07-2 N-(1-[4-chloro-phenyl]-1H-[1,2,3]triazol-4-ylmethyl)-morpholine 
• 2866-82-2 N-(4-chlorophenyl)benzamide 
• 170944-20-4 2-diazo-3-oxo-N-(4-chlorophenyl)-butanamide 

Relevant articles and documents

Design and synthesis of 1,4-disubstituted 1,2,3-triazoles: Biological evaluation, in silico molecular docking and ADME screening

In this study, propargyl compounds were synthesized from 4-hydroxybenzaldehyde and 3?methoxy-4-hydroxybenzaldehyde (2a-2b). As a result of click reactions of synthesized propargyl compounds (2a-b) with organic azides (4a-4e), carbonyl compounds (5a-5 h) h

Synthesis and antitumor activity of 1-substituted 1,2,3-triazole-mollugin derivatives

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.

Triazole [5, 4-d] pyrimidone tricyclic compounds as well as preparation method and application thereof

The invention relates to triazole [5, 4-d] pyrimidone tricyclic compounds as well as a preparation method and application thereof.The triazole [5, 4-d] pyrimidone tricyclic compounds are prepared by following steps: taking different substituted anilines a