1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone

Base Information

• Chemical Name: 1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone
• CAS No.: 58375-08-9
• Molecular Formula: C17H12ClNO2
• Molecular Weight: 297.73600
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70350428
• Wikidata: Q82126368
• ChEMBL ID: CHEMBL1491535
• Mol file: 58375-08-9.mol

Synonyms:58375-08-9;1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone;3-Acetyl-6-chloro-4-phenyl-1H-quinolin-2-one;3-acetyl-6-chloro-4-phenylquinolin-2(1H)-one;3-acetyl-6-chloro-4-phenyl-1,2-dihydroquinolin-2-one;1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)-ethanone;F0010-0580;Maybridge1_000865;Cambridge id 5849265;MLS000713991;SCHEMBL6059495;CHEMBL1491535;HMS543P07;DTXSID70350428;AJBGMDVXSIBMLC-UHFFFAOYSA-N;HMS2627I07;CCG-18387;MFCD00116018;STK167584;AKOS000638868;AKOS001650570;AT27461;SB68874;AS-69783;SMR000273472;FT-0704481;EN300-236060;AB00099206-01;AB00099206-02;SR-01000462073;SR-01000462073-1;SR-01000462073-2;Z1636233591

Chemical Property of 1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone

Chemical Property:

• PSA: 50.19000
• LogP: 4.46340
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 297.0556563
• Heavy Atom Count: 21
• Complexity: 479

Purity/Quality:

98%min ^*data from raw suppliers

1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)-ethanone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C2=C(C=CC(=C2)Cl)NC1=O)C3=CC=CC=C3

Technology Process of 1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone

There total 1 articles about 1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl acetoacetate (141-97-9) + 5-chloro-2-aminobenzophenone (719-59-5) → 3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one (58375-08-9)

Guidance literature:

In N,N-dimethyl-formamide; at 153 ℃; for 19h; Sealed tube;

DOI:10.1021/acs.jmedchem.9b01526

Reference yield: 99.0%

3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one (58375-08-9) + 3-pyridinecarboxaldehyde (500-22-1) → (E)-6-chloro-4-phenyl-3-(3-(pyridin-3-yl)acryloyl)quinolin-2(1H)-one

Guidance literature:

3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one; With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.75h;

3-pyridinecarboxaldehyde; In ethanol; water; at 0 - 20 ℃; for 16h;

Reference yield: 88.0%

3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one (58375-08-9) + 4-methyl-benzaldehyde (104-87-0) → 6-chloro-4-phenyl-3-[(E)-3-(p-tolyl)prop-2-enoyl]-1H-quinolin-2-one

Guidance literature:

3-acetyl-6-chloro-4-phenylquinolin-2-(1H)-one; With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.75h;

4-methyl-benzaldehyde; In ethanol; water; at 20 ℃; for 16h;

upstream raw materials:

ethyl acetoacetate

5-chloro-2-aminobenzophenone

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