3-Methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-Methylimidazo[1,2-a]pyridine
• CAS No.: 5857-45-4
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30481500
• Nikkaji Number: J2.945.001C
• Wikidata: Q82316946
• Mol file: 5857-45-4.mol

Synonyms:3-methylimidazo[1,2-a]pyridine;5857-45-4;MFCD09834779;SCHEMBL84864;DTXSID30481500;DLTHEPWEENQLKV-UHFFFAOYSA-N;AKOS006329395;BS-29255;SY318985;CS-0208931;FT-0684614

Chemical Property of 3-Methylimidazo[1,2-a]pyridine

Chemical Property:

• PSA: 17.30000
• LogP: 1.64270
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 132.068748264
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

98%min ^*data from raw suppliers

3-Methylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C2N1C=CC=C2

Technology Process of 3-Methylimidazo[1,2-a]pyridine

There total 14 articles about 3-Methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate (1284210-49-6) → 3-methylimidazo[1,2-α]pyridine (5857-45-4)

Guidance literature:

With water; at 120 ℃; for 1h; Solvent; Temperature; Time; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2013.08.112

Reference yield: 97.0%

N-(prop-2-yn-1-yl)pyridin-2-amine (117459-95-7) → 3-methylimidazo[1,2-α]pyridine (5857-45-4)

Guidance literature:

In water; at 120 ℃; for 1h; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere; Sealed tube;

DOI:10.1021/jo3025303

Reference yield: 97.0%

2-aminopyridine (504-29-0) + propionaldehyde (123-38-6) → 3-methylimidazo[1,2-α]pyridine (5857-45-4)

Guidance literature:

With sulfur; In cyclohexane; dimethyl sulfoxide; at 120 ℃; for 1h; Sealed tube;

DOI:10.1039/c8ob00981c

upstream raw materials:

[2]pyridylamino-acetone

acetic anhydride

1-(2-pyridinylamino)-2-nitroprene

2-(N-formyl-N-prop-2'-inyl)aminopyridin

Downstream raw materials:

imidazo[1,2-a]pyridine-3-carbaldehyde

3-hydroxymethylimidazo[1,2-a]pyridine

2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde

(2-(4-chlorophenyl)imidazo [1,2-a] pyridin-3-yl)methanol

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