117459-95-7

Upstream product

• 34813-97-3 2-(formylamino)pyridine 
• 106-96-7 propargyl bromide 
• 1284210-49-6 tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 504-29-0 2-aminopyridine 
• 694-59-7 pyridine N-oxide 
• 15430-52-1 prop-2-yn-1-amine hydrochloride 

Downstream Products

• 1309357-89-8 (E)-3-(iodomethylene)-2,3-dihydro-1H-imidazo[1,2-a]pyridin-4-ium iodide 
• 6188-43-8 imidazo[1,2-a]pyridine-3-carbaldehyde 
• 6200-59-5 imidazo[1,2-a]pyridine-3-carbonitrile 
• 30493-06-2 2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 5857-45-4 3-methylimidazo[1,2-α]pyridine 
• 30489-43-1 3-hydroxymethylimidazo[1,2-a]pyridine 
• 30489-48-6 (2-(4-chlorophenyl)imidazo [1,2-a] pyridin-3-yl)methanol 
• 103845-12-1 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-yl)methyl)butyramide 
• 103844-86-6 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N-methylbutyramide 
• 101820-69-3 imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester 

Relevant academic research and scientific papers

ANTI-ALPHAVBETA1 INTEGRIN INHIBITORS AND METHODS OF USE

Provided herein, inter alia, are methods and compositions for inhibiting ανβ? integrin and for treating fibrosis.

Anti-methicillin resistant Staphylococcus aureus activity, synergism with oxacillin and molecular docking studies of metronidazole-triazole hybrids

MRSA causes 60-70% of Staphylococcus aureus infection in hospitals and it has developed resistance against the currently available drugs. Interestingly, a series of 35 metronidazole-triazole hybrids on screening against MRSA were found to be active. Compound 22 was found to be effective at 4 μg/mL concentration against nine strains of MRSA. The inhibitory activity was further enhanced upto 1 μg/mL when this compound was used in combination with oxacillin in 1:1 ratio. All the compounds were found to be non-toxic in THP-1 cell line upto a concentration of 50 μM. The time-kill kinetics studies suggested bacteriostatic nature of the compounds. In silico studies show that these compounds interact with Thr600, Ser598, Asn464, His583 and Tyr446 in the active site of PBP2a crystal structure from MRSA.

Silver-catalyzed cyclization of N-(prop-2-yn-1-yl)pyridin-2-amines

We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl)pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines. The isomerization reactions proce

A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines

The Sandmeyer reaction of differently C-2 substituted N-(prop-2-yn-1- ylamino)pyridines is an efficient, mild, new and practical method for the stereospecific synthesis of (E)-exo-halomethylene bicyclic pyridones bearing the imidazo[1,2-a]pyridine heteroc

Acetylenchemie. 9. Mitt. Anellierte Imidazole aus N-Propinylamid-Vorstufen

The compound 2-(N-formyl-N-prop-2'-inyl)aminopyridine was cyclised in boiling formic acid to 3-methylimidazopyridine, with 3-methylene-2H-imidazopyridine as the intermediate.Under similar conditions the 1,3-diprop-2-inylpyrimidoquinoline-2,4-dione resulted from 1-methylimidazoquinoline-4-carbonic acid-N-2-prop-2'-inylamide and from the 1-prop-2'inylbenzonaphthyridin-2-one the 1-methylbenzoimidazonaphthyridine-4,7-dione as a new ring system, was obtained.