Cyclohexanecarbothioic acid, S-2-pyridinyl ester

Base Information

• Chemical Name: Cyclohexanecarbothioic acid, S-2-pyridinyl ester
• CAS No.: 58587-04-5
• Molecular Formula: C12H15NOS
• Molecular Weight: 221.323
• Mol file: 58587-04-5.mol

Synonyms:

Chemical Property of Cyclohexanecarbothioic acid, S-2-pyridinyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarbothioic acid, S-2-pyridinyl ester

There total 6 articles about Cyclohexanecarbothioic acid, S-2-pyridinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + 1-cyclohexanecarbonyl-1H-imidazole (60718-45-8) → S-(pyridin-2-yl)-cyclohexanecarbothioate (58587-04-5)

Guidance literature:

With magnesium ethylate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(01)81874-8

Reference yield: 76.0%

2,2'-dipyridyldisulphide (2127-03-9) + Cyclohexanecarboxylic acid (98-89-5) → S-(pyridin-2-yl)-cyclohexanecarbothioate (58587-04-5)

Guidance literature:

With triphenylphosphine; In acetonitrile;

DOI:10.1039/c9sc01817d

Reference yield: 46.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + cyclohexanylcarbonyl chloride (2719-27-9) → S-(pyridin-2-yl)-cyclohexanecarbothioate (58587-04-5)

Guidance literature:

In tetrahydrofuran; at 19 - 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201700913

upstream raw materials:

2-Sulfanylpyridine

potassium 1-cyclohexyl methanoate

1,2-bis(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)ethane-1,2-dione

1-cyclohexanecarbonyl-1H-imidazole

Downstream raw materials:

cyclohexyl-(1H-pyrrol-2-yl)methanone

1,2-dicyclohexyl-2-hydroxy-ethanone

1,2-dicyclohexylethanedione

cyclohexene