3-(2,6-Dimethylanilino)oxolan-2-one

Base Information

Chemical Name:3-(2,6-Dimethylanilino)oxolan-2-one
CAS No.:58810-61-0
Molecular Formula:C12H15NO2
Molecular Weight:205.257
Hs Code.:
ChEMBL ID:CHEMBL2206937
DSSTox Substance ID:DTXSID30500240

Synonyms:3-(2,6-Dimethylanilino)oxolan-2-one;58810-61-0;N-(2-oxotetrahydro-3-furyl)-2,6-dimethylaniline;SCHEMBL9620022;CHEMBL2206937;DTXSID30500240;QNCHSVFDXFQFLD-UHFFFAOYSA-N;N-(tetrahydro-2-oxo-3-furanyl)-2,6-dimethylbenzeneamine

Suppliers and Price of 3-(2,6-Dimethylanilino)oxolan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2,6-Dimethylanilino)oxolan-2-one

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:205.110278721
Heavy Atom Count:15
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C)NC2CCOC2=O

Technology Process of 3-(2,6-Dimethylanilino)oxolan-2-one

There total 1 articles about 3-(2,6-Dimethylanilino)oxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 5061-21-2
α-bromo-γ-butyrolactone

: 87-62-7
2,6-dimethylaniline

: 58810-61-0
<(2,6-Dimethylphenyl)amino>-dihydro-2(3H)-furanone

Guidance literature:: With potassium carbonate; In toluene; at 80 ℃; for 5h;
DOI:10.1016/j.bmc.2012.08.037 DOI:10.1016/j.bmc.2012.08.037

Reference yield:

: 38870-89-2
Methoxyacetyl chloride

: 58810-61-0
<(2,6-Dimethylphenyl)amino>-dihydro-2(3H)-furanone

: 67932-71-2
N-(2,6-dimethylphenyl)-2-methoxy-N-(tetrahydro-2-oxo-3-furanyl)-acetamide

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene;

Reference yield:

: 58810-61-0
<(2,6-Dimethylphenyl)amino>-dihydro-2(3H)-furanone

: 117144-03-3
(3R)-N-(2,6-Dimethylphenyl)-2-methoxy-N-(tetrahydro-2-oxo-3-furanyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) m-CPBA, 2) basic alumina / 1) THF, 0 deg C, 1 h

2: 23.2 percent / DMF / toluene / 48 h / Heating; reduced pressure

3: 65.4 percent / H₂ / Ru(OAc)2(S)-BINAP / methanol / 43 h / 50 °C / 71255.7 Torr

With aluminum oxide; hydrogen; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; Ru(OCOCH₃)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; In methanol; toluene;
DOI:10.1016/S0040-4020(01)86523-6