38870-89-2

Basic information

• Product Name: Methoxyacetyl chloride
• Synonyms: METHOXYACETYL CHLORIDE, STAB.;Methoxyacetyl chloride, stabilized, ca. 95%;MEYHOXY ACETYL CHLORIDE;Methoxyacetyl chloride, GC 95%;Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide;Methoxyacetyl Chloride [Chloromethylating Reagent];Methoxyacetyl chloride, ca. 95%, stabilized;Methoxyacetyl chloride, stabilized
• CAS NO: 38870-89-2
• Molecular Formula: C₃H₅ClO₂
• Molecular Weight: 108.52
• EINECS: 254-169-2
• Product Categories: Chlorination;Halogenation;Synthetic Organic Chemistry;NULL
• Mol File: 38870-89-2.mol
• Article Data: 45

Chemical Properties

• Melting Point: <-40°C
• Boiling Point: 112-113 °C(lit.)
• Flash Point: 84 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.19 g/mL at 20 °C
• Vapor Pressure: 21.7mmHg at 25°C
• Refractive Index: n20/D 1.419(lit.)
• Storage Temp.: 2-8°C
• Solubility: Miscible with acetone, ether, carbon tetrachloride and chlorofor
• Water Solubility: reacts
• Sensitive: Moisture Sensitive
• BRN: 1740244
• CAS DataBase Reference: Methoxyacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methoxyacetyl chloride(38870-89-2)
• EPA Substance Registry System: Methoxyacetyl chloride(38870-89-2)

Safety Data

• Hazard Codes: C
• Statements: 10-34-36/37
• Safety Statements: 26-36/37/39-45-25-16
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• F: 9-19-21
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 38870-89-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals.

InChI:InChI=1/C3H5ClO2/c1-6-2-3(4)5/h2H2,1H3

Upstream product

• 625-45-6 2-methoxyacetic acid 
• 124-41-4 sodium methylate 
• 79-11-8 chloroacetic acid 
• 383865-57-4 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 
• 107-30-2 chloromethyl methyl ether 
• 201230-82-2 carbon monoxide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 103209-94-5 4-(2-methoxyacetoxy-3,5-dimethyl-phenyl)-2-(2-methoxycarbonyl-6,8-dimethyl-4-oxo-chroman-3-yl)-4-oxo-butyric acid methyl ester 
• 37958-33-1 7c-methoxy-6-phenyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octan-8-one 
• 69506-29-2 [(2,6-Diethyl-phenyl)-(2-methoxy-acetyl)-amino]-acetic acid methyl ester 
• 75150-61-7 Methoxy-acetic acid N'-[5-(2-chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenyl]-hydrazide 
• 121003-13-2 N-methoxyacetyl-ε-thiocaprolactam 
• 103439-23-2 4-Methoxy-2,2-dimethyl-3-oxo-butyryl chloride 
• 74687-08-4 N-Benzhydrylidene-2-methoxy-acetamide 
• 109324-63-2 N-Benzyl-2-methoxy-N-(6-oxo-cyclohex-1-enyl)-acetamide 
• 733-07-3 dimesitylmethane 
• 148475-65-4 7-n-Propyl-5-methyl-2-methoxymethyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidine 
• 161972-97-0 cis-1-benzyl-4-[(3aαH,8bαH)-tetrahydro-2,2,7,7-tetrahydro-2,2,7,7-tetramethyl-5H-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-5-yl]-3-methoxy-azetidin-2-one 
• 161742-53-6 2'-O-(methoxyacetyl)paclitaxel 
• 162490-36-0 (E)-3-{(2R,3S)-1-[(R)-2,2-Bis-propylsulfanyl-1-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethyl]-3-methoxy-4-oxo-azetidin-2-yl}-acrylic acid benzyl ester 
• 162490-37-1 (E)-3-{(2R,3S)-1-[(R)-2,2-Bis-propylsulfanyl-1-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-ethyl]-3-methoxy-4-oxo-azetidin-2-yl}-acrylic acid benzhydryl ester 

Relevant articles and documents

A Diels-Alder reaction for the total synthesis of the novel antibiotic antitumor agent mensacarcin

The antibiotic mensacarcin (1), which contains nine stereogenic centers and two epoxy functionalities, is a novel antitumor agent that was first isolated from the culture broth of Streptomyces sp. Goe C4/4 found in a soil sample next to the northern cafeteria of the University of Goettingen. For the synthesis of 1 and related structurally simplified analogs, a Diels-Alder reaction of O-methyljuglone (11) and the tetra-substituted 1,3-butadiene 22 was performed to give the cycloadduct rac-28, which was transformed into the epoxides rac-31 and rac-33. The cytotoxicity of rac-33 is only 53 times lower than the much more complex 1. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Preparation method and application of iopromide intermediate (by machine translation)

The invention relates to a preparation method of an iopromide intermediate and an application thereof in preparation of iopromide. The method comprises the following steps: compound VI compound is subjected to reduction reaction under the action of Raney nickel/hydrazine hydrate to obtain the compound V compound. The reaction is carried out under normal pressure, the operation is simple and safe, the generated intermediate impurities are less, and the reaction is more suitable for industrial production. The method is used for preparing iopromide, can avoid the generation of a diacylated by-product, can effectively reduce the generation of by-products in the preparation process, can be easily separated and purified, and can obtain high-purity iopromide with high yield. (by machine translation)

Synthesis method of optically active metalaxyl

The invention discloses a synthesis method of optically active metalaxyl. The optically active metalaxyl is synthesized by performing methoxylation and acylating chlorination on chloroacetic acid to obtain methoxyacetyl chloride and then reacting Methoxyacetyl chloride with D-N-(2,6-dimethylphenyl) alanine methyl ester; a one-pot method operation is adopted for the synthesis; the two-step reactionof methoxylation and acylating chlorination is directly used for a next-step reaction without post-treatment. According to the process of the optically active metalaxyl, by adopting the one-pot method operation, the operation steps are simplified, the production of three wastes is decreased, the synthesis cost is reduced, the obtained product is stable in quality and relatively high in output andyield, and the synthesis method is suitable for large-scale production.