N-acetyl-N-methylglycine

Base Information

• Chemical Name: N-acetyl-N-methylglycine
• CAS No.: 5888-91-5
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.131
• Hs Code.: 2922499990
• UNII: 7QC829R9F7
• DSSTox Substance ID: DTXSID70450336
• Nikkaji Number: J842.409H
• Mol file: 5888-91-5.mol

Synonyms:5888-91-5;N-acetyl-N-methylglycine;2-(N-Methylacetamido)acetic acid;2-[ACETYL(METHYL)AMINO]ACETIC ACID;Glycine, N-acetyl-N-methyl-;N-acetylsarcosine;acetylsarcosine;7QC829R9F7;MFCD00021748;N-Acetyl-N-methyl-glycine;[acetyl(methyl)amino]acetic acid;N-acetyl sarcosine;N-acetyl-sarcosine;Sarcosine, N-acetyl-;UNII-7QC829R9F7;SCHEMBL1597034;2-(N-Methylacetamido)aceticacid;DTXSID70450336;SVXPSKKRNACRPB-UHFFFAOYSA-N;AKOS000126613;BS-13029;SY168740;[acetyl(methyl)amino]acetic acid, AldrichCPR;BB 0259291;CS-0169319;EN300-33657;Z85895184

Chemical Property of N-acetyl-N-methylglycine

Chemical Property:

• PSA: 57.61000
• LogP: -0.45070
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 131.058243149
• Heavy Atom Count: 9
• Complexity: 132

Purity/Quality:

98%min ^*data from raw suppliers

N-Acetyl-N-methyl-glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C)CC(=O)O

Technology Process of N-acetyl-N-methylglycine

There total 1 articles about N-acetyl-N-methylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sarcosine (107-97-1,25951-24-0) + 4-nitrophenol acetate (830-03-5) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N-acetylsarcosine (5888-91-5)

Guidance literature:

With water; In dimethyl sulfoxide; at 25 ℃; Further Variations:; Solvents; Kinetics;

DOI:10.1002/chem.200401067

Reference yield: 98.0%

N-acetylsarcosine (5888-91-5) + tert-butyl 3-((2-(benzyloxy)-2-oxoethyl)amino)propanoate (189056-58-4) → 3-{[2-(Acetyl-methyl-amino)-acetyl]-benzyloxycarbonylmethyl-amino}-propionic acid tert-butyl ester (189056-59-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1016/S0008-6215(96)00301-1

Reference yield: 81.0%

N-acetylsarcosine (5888-91-5) + [(2-{(2-{Benzyl-[2-(4-tert-butoxycarbonylamino-butylamino)-acetyl]-amino}-acetyl)-[((2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-2-ylcarbamoyl)-methyl]-amino}-acetyl)-isobutyl-amino]-acetic acid tert-butyl ester → C53H82N8O18

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; tert-butyl alcohol; for 3h; Ambient temperature;

DOI:10.1016/0040-4039(95)00620-R

upstream raw materials:

sarcosine

4-nitrophenol acetate

Downstream raw materials:

N-acetonyl-N-methyl-acetamide

N-acetamidoacetone

Ac-Sar-benzylamide

(Acetyl-methyl-amino)-thioacetic acid S-phenyl ester