Phosphoric acid, [1-[[(5R)-3-[4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl ]-2-oxo-5-oxazolidinyl]methyl]-1H-1,2,3-triazol-4-yl]methyl diphenyl ester

Base Information

Chemical Name:Phosphoric acid, [1-[[(5R)-3-[4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl ]-2-oxo-5-oxazolidinyl]methyl]-1H-1,2,3-triazol-4-yl]methyl diphenyl ester
CAS No.:591253-34-8
Molecular Formula:C30H28FN4O8PS
Molecular Weight:654.612
Hs Code.:

Phosphoric acid,
[1-[[(5R)-3-[4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl
]-2-oxo-5-oxazolidinyl]methyl]-1H-1,2,3-triazol-4-yl]methyl diphenyl ester

Synonyms:

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Chemical Property of Phosphoric acid, [1-[[(5R)-3-[4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl ]-2-oxo-5-oxazolidinyl]methyl]-1H-1,2,3-triazol-4-yl]methyl diphenyl ester

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phosphoric acid, [1-[[(5R)-3-[4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl ]-2-oxo-5-oxazolidinyl]methyl]-1H-1,2,3-triazol-4-yl]methyl diphenyl ester

There total 3 articles about Phosphoric acid, [1-[[(5R)-3-[4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl ]-2-oxo-5-oxazolidinyl]methyl]-1H-1,2,3-triazol-4-yl]methyl diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 591253-26-8
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[(4-(hydroxymethyl)-1,2,3-triazol-1-yl)methyl]oxazolidin-2-one

: 591253-34-8
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-[(diphenoxyphosphonyl)oxymethyl]-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jm0400810

Reference yield:

: 371195-52-7
(5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-azidomethyloxazolidin-2-one

: 591253-34-8
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-[(diphenoxyphosphonyl)oxymethyl]-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2.5 h / 0 - 20 °C

2: 50 percent / N-methylpyrrolidone / 4 h / 90 °C

3: 80 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

With pyridine; 1-methyl-pyrrolidin-2-one; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm0400810

Reference yield:

: 591231-86-6
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-(azidomethyl)oxazolidin-2-one

: 591253-34-8
(5R)-3-[4-(1,1-dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-[(diphenoxyphosphonyl)oxymethyl]-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / N-methylpyrrolidone / 4 h / 90 °C

2: 80 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

With pyridine; 1-methyl-pyrrolidin-2-one; In dichloromethane;
DOI:10.1021/jm0400810