3-Methyl-2-azaspiro[4.5]decane

Base Information

• Chemical Name: 3-Methyl-2-azaspiro[4.5]decane
• CAS No.: 592478-37-0
• Molecular Formula: C10H19N
• Molecular Weight: 153.26500
• DSSTox Substance ID: DTXSID00447133
• Nikkaji Number: J2.124.307H
• Mol file: 592478-37-0.mol

Synonyms:3-Methyl-2-azaspiro[4.5]decane;592478-37-0;SCHEMBL9000263;DTXSID00447133;2-Aza-3-methylspiro[4.5]decane;AKOS006330384

Chemical Property of 3-Methyl-2-azaspiro[4.5]decane

Chemical Property:

• PSA: 12.03000
• LogP: 2.64750
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 153.151749610
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2(CCCCC2)CN1

Technology Process of 3-Methyl-2-azaspiro[4.5]decane

There total 15 articles about 3-Methyl-2-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-allyl-1-(aminomethyl)cyclohexane (81097-43-0) → 3-methyl-2-azaspiro[4.5]decane (592478-37-0)

Guidance literature:

With Y(C₅(CH₃)4Si(CH₃)2NCN₂(CH(CH₃)2)2C₂(CH₃)2)(CH₂Si(CH₃)3)2; In benzene-d6; at 20 ℃; for 0.05h;

DOI:10.1002/ejic.200800606

Reference yield: 96.0%

1-allyl-1-(aminomethyl)cyclohexane (81097-43-0) → (R)-3-methyl-2-azaspiro[4.5]decane (592478-37-0)

Guidance literature:

With C₃₁H₄₉BN₄O₂Zr⁽²⁺⁾; In benzene-d6; at 20 ℃; for 1.25h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja4000189

Reference yield:

1-allyl-1-(aminomethyl)cyclohexane (81097-43-0) → C-(1-propenyl-cyclohexyl)-methylamine + 3-methyl-2-azaspiro[4.5]decane (592478-37-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 50 ℃; for 24h;

DOI:10.1002/ejoc.200300058

upstream raw materials:

1-allyl-1-(aminomethyl)cyclohexane

1-allylcyclohexane-1-nitrile

cyclohexane carbonitrile

Downstream raw materials:

2-(4-chlorophenethyl)-3-methyl-2-azaspiro[4,5]decane

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