81097-43-0

Upstream product

• 67838-03-3 1-(1-(2-propenyl)cyclohexyl)methanol 
• 72335-77-4 1-Allyl-cyclohexanecarboxylic acid amide 
• 676132-37-9 1-allylcyclohexane-1-nitrile 
• 766-05-2 cyclohexane carbonitrile 
• 67838-02-2 methyl 1-allylcyclohexane-1-carboxylate 
• 72335-83-2 1-allylcyclohexane-1-carboxylic acid chloride 
• 72335-50-3 1-(1-prop-2-enyl)cyclohexanecarboxylic acid 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 2043-61-0 cyclohexanecarbaldehyde 
• 29517-58-6 1-allylcyclohexanecarbaldehyde 

Downstream Products

• 592478-37-0 3-methyl-2-azaspiro[4.5]decane 
• 592478-44-9 (1-allylcyclohexyl)-N-benzylmethanamine 
• 869804-08-0 (±)-N-(((1-allylcyclohexyl)methyl)carbamoyl)-4-methylbenzenesulfonamide 
• 592478-37-0 3-methyl-2-aza-spiro[4,5]decane 
• 592478-37-0 3-methyl-2-aza-spiro[4,5]decane 
• 916229-42-0 methyl-4-[(1-allyl-cyclohexylmethyl)carbamoyl]butyrate 
• 882301-73-7 C₁₉H₃₃N₃O₄ 
• 81097-23-6 N-tosyl-3-methyl-2-azaspiro<5,6>undec-3-ene 
• 134786-21-3 N-tosyl-2-azaspiro<4,5>decane-3-methanol 
• 134786-29-1 N-tosyl-α,α-dimethyl-2-azaspiro<4,5>decane-3-methanol 
• 134786-33-7 acide N-tosyl-2-azaspiro<4,5>decane-3-carboxylique 
• 1062120-37-9 C₁₀H₁₆⁽²⁾H₃N 
• 1124311-77-8 N-((1-allylcyclohexyl)methyl)-4-methylbenzamide 
• 1203580-05-5 (1-allylcyclohexylmethyl)-N-phenylamine 

Relevant academic research and scientific papers

HDAC6 INHIBITORS AND USES THEREOF

Provided herein are compounds that inhibit HDAC6, a protein whose activity is associated with a variety of diseases (e.g., cancer, neurological disorders). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of tre

Asymmetric "clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines

The development of an asymmetric "clip-cycle"synthesis of 2,2- and 3,3-disubstituted pyrrolidines and spiropyrrolidines, which are increasingly important scaffolds in drug discovery programs, is reported. Cbz-protected bis-homoallylic amines were activate

Palladium(II)-Catalyzed Aminotrifluoromethoxylation of Alkenes: Mechanistic Insight into the Effect of N-Protecting Groups

An efficient palladium-catalyzed regioselective 5-exo aminotrifluoromethoxylation of alkenes has been established herein, which provides a practical route towards the synthesis of OCF3-containing pyrrolidines. tert-Butyloxycarbonyl (Boc) as an amino protecting group plays a significant role in both the chemo- and regioselectivities. In addition, preliminary mechanistic studies reveal that the amino protecting group of substrates and the counter anion of palladium catalyst play critical roles in reaction efficiency presumably due to an isomerization of alkyl- Pd(II) intermediates. Moreover, the asymmetric 5-exo aminotrifluoromethoxylation reaction has also been achieved by introducing a sterically bulky pyridinyl-oxazoline ligand.

Enantioselective Synthesis of Pyrrolizidinone Scaffolds through Multiple-Relay Catalysis

A triple-tandem protocol for the synthesis of the pyrrolizidinone skeleton has been devised. It involves a cross metathesis-intramolecular aza-Michael reaction-intramolecular Michael addition tandem sequence, starting from N-pentenyl-4-oxo-2-alkenamides and conjugated ketones. In the presence of two cooperative catalysts, namely the second-generation Hoveyda-Grubbs catalyst and (R)-TRIP-derived BINOL phosphoric acid, this multiple-relay catalytic process takes place in good yields and outstanding levels of diastero- and enantioselectivity with the simultaneous generation of three contiguous stereocenters

One-pot Construction of Difluorinated Pyrrolizidine and Indolizidine Scaffolds via Copper-Catalyzed Radical Cascade Annulation

A convenient approach to the synthesis of diverse difluorinated nitrogen-containing polycycles via a copper-catalyzed radical cascade annulation of amine-containing olefins and ethyl bromodifluoroacetate was developed. Three new bonds, including a Csp3 ?CF2 and two C?N bonds, are forged simultaneously in this strategy. Through this strategy, a series of difluorinated pyrrolizidine and indolizidine derivatives have been conveniently synthesized in good yields. (Figure presented.).

Enantioselective Pd(II)-Catalyzed Intramolecular Oxidative 6- endo Aminoacetoxylation of Unactivated Alkenes

A novel asymmetric 6-endo aminoacetoxylation of unactivated alkenes by palladium catalysis, which yields chiral β-acetoxylated piperidines with excellent chemo-, regio- and enantioselectivities under very mild reaction conditions, has been established herein by employing a new designed pyridine-oxazoline (Pyox) ligand. Importantly, introducing a sterically bulky group into the C-6 position of Pyox is crucial to enhance the reactivity of the aminoacetoxylation of alkenes.

Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides

The catalyst system of Pd(TFA)2/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. A series of pyrrolizidine derivatives have been synthesized in good yield and excellent enantioselectivity. Deuterium-labeling experiments have revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step have been calculated to account for the observed enantioselectivity.

Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles

A highly efficient palladium-catalyzed intramolecular aminoalkylation of unactivated alkenes in the absence of an external ligand and oxidant is described. New C-N and C(sp3)-C(sp3) bonds are formed simultaneously. This general transformation allows for construction of diverse N-heterocycles. Mechanistic studies show that the process may involve a four-membered Pd(alkyl)amido intermediate.

I2-Mediated oxidative bicyclization of 4-pentenamines to prolinol carbamates with CO2 incorporating oxyamination of the C=C bond

A metal-free oxyamination reaction of alkenes with ambient CO2 is reported. In the presence of I2 and DBU, CO2 is applied in situ as a protecting group to regulate the nucleophilicity of the amino group and facilitate the bicyclization of 4-pentenamines with high chemoselectivity. Moreover, this reaction provided a feasible approach to prepare prolinol carbamates with good tolerance of functional groups and high efficiency under mild conditions.

Copper(II)-catalyzed enantioselective intramolecular cyclization of N-alkenylureas

The first Cu(II)-catalyzed highly enantioselective intramolecular cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.