(E)-2',4',6'-triMethoxystyryl-4-Methoxy-3-aMinobenzylsulfone, (E)-5-((2,4,6-triMethoxystyrylsulfonyl)Methyl)-2-MethoxybenzeneaMine

Base Information

• Chemical Name: (E)-2',4',6'-triMethoxystyryl-4-Methoxy-3-aMinobenzylsulfone, (E)-5-((2,4,6-triMethoxystyrylsulfonyl)Methyl)-2-MethoxybenzeneaMine
• CAS No.: 592542-50-2
• Molecular Formula: C19H23NO6S
• Molecular Weight: 393.461
• Mol file: 592542-50-2.mol

Synonyms:(E)-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxybenzenamine;(E)-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxybenzeneamine;(E)-2,4,6-trimethoxystyryl-3'-amino-4'-methoxybenzylsulfone;(E)-2,4,6-trimethoxystyryl-4-methoxy-3-aminobenzylsulfone;(E)-2',4',6'-trimethoxystyryl-4-methoxy-3-aminobenzylsulfone;

Chemical Property of (E)-2',4',6'-triMethoxystyryl-4-Methoxy-3-aMinobenzylsulfone, (E)-5-((2,4,6-triMethoxystyrylsulfonyl)Methyl)-2-MethoxybenzeneaMine

Chemical Property:

• Melting Point: 146-148 °C
• Boiling Point: 661.2±55.0 °C(Predicted)
• PKA: 3.96±0.10(Predicted)
• PSA: 105.46000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 4.55090

Purity/Quality:

98.5% ^*data from raw suppliers

5-((2,4,6-TRIMETHOXYSTYRYLSULFONYL)METHYL)-2-METHOXYBENZENAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2',4',6'-triMethoxystyryl-4-Methoxy-3-aMinobenzylsulfone, (E)-5-((2,4,6-triMethoxystyrylsulfonyl)Methyl)-2-MethoxybenzeneaMine

There total 12 articles about (E)-2',4',6'-triMethoxystyryl-4-Methoxy-3-aMinobenzylsulfone, (E)-5-((2,4,6-triMethoxystyrylsulfonyl)Methyl)-2-MethoxybenzeneaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(E)-2',4',6'-trimethoxystyryl-4-methoxy-3-aminobenzyl sulfide (908344-08-1) → (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)aniline (592542-50-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm200570p

Reference yield:

(E)-2,4,6-trimethoxystyryl-3'-amino-4'-methoxybenzylsulfone acetate → (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)aniline (592542-50-2)

Guidance literature:

With sodium hydroxide; In water; at 10 - 20 ℃; for 3h; pH=7.5 - 8.5; Product distribution / selectivity;

Reference yield:

4-methoxy-3-nitrophenylmethanesulfonyl acetic acid (592542-51-3) → (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)aniline (592542-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / pyridine / 36 h / 20 °C

With piperidine; In pyridine;

DOI:10.1016/j.bmcl.2011.03.041

upstream raw materials:

2-(4-methoxy-3-nitrobenzylthio)acetic acid

4-methoxy-3-nitrophenylmethanesulfonyl acetic acid

3-nitro-4-methoxybenzyl bromide

(E)-2',4',6'-trimethoxystyryl-4-methoxy-3-aminobenzyl sulfide

Downstream raw materials:

(E)-methyl 2-(2-methoxy-5-((2',4',6'-trimethoxystyrylsulfonyl)methyl)phenylamino)acetate

(E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic acid

(E)-2,4,6-trimethoxystyryl-3-(acetamido)-4-methoxybenzylsulfone

(E)-3-(2-methoxy-5-((2',4',6'-trimethoxystyrylsulfonyl)methyl)phenylamino)propanoic acid