4-BENZYLANILINE

Base Information

• Chemical Name: 4-BENZYLANILINE
• CAS No.: 1135-12-2
• Molecular Formula: C13H13N
• Molecular Weight: 183.253
• Hs Code.: 2921490090
• Mol file: 1135-12-2.mol

Synonyms:p-Toluidine,a-phenyl- (6CI,7CI,8CI);4-(Phenylmethyl)aniline;4-Aminodiphenylmethane;4-Benzylaniline;4-Benzylbenzenamine;4-Benzylphenylamine;p-Aminodiphenylmethane;p-Benzylaniline;

Chemical Property of 4-BENZYLANILINE

Chemical Property:

• Appearance/Colour: Colorless to yellow transparent liquid
• Vapor Pressure: 0.00115mmHg at 25°C
• Melting Point: 35-38 °C(lit.)
• Refractive Index: 1.616
• Boiling Point: 300 °C at 760 mmHg
• PKA: 2.17(at 25℃)
• Flash Point: 159.5 °C
• PSA: 26.02000
• Density: 1.07 g/cm³
• LogP: 3.44080
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Benzylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Benzylaniline (4-Aminodiphenylmethane) can be used to synthesize:2-amino-6-benzylbenzothiazole (SKA-7)ethyl 2-((4-benzylphenylamino)methylen)-malonatebis(4-benzylphenyl)-urea3:5-dibromo-4-aminodiphenylmethane via treatment with bromine solution3:5-di-iodo-4-aminodiphenylmethane via iodination reaction by using a suitable iodinating reagent[sodium iodate + potassium iodide]

Technology Process of 4-BENZYLANILINE

There total 28 articles about 4-BENZYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzylzinc chloride-lithium chloride complex + 4-bromo-aniline (106-40-1) → p-benzylaniline (1135-12-2)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; bis(acetylacetonate)nickel(II); triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo8015852

Reference yield: 85.0%

4'-aminobenzophenone hydrochloride → p-benzylaniline (1135-12-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In perchloric acid; acetic acid; at 20 ℃; for 18h; under 2275.45 Torr;

Reference yield: 82.2%

4-nitrobenzophenone (1144-74-7) → p-benzylaniline (1135-12-2)

Guidance literature:

With potassium hydroxide; Raney Ni-Al alloy; In water; at 90 ℃; for 9h;

DOI:10.1080/00397910801929762

upstream raw materials:

4-benzyl-1-nitrobenzene

1-(4-benzylphenyl)ethanone

4-methoxymethyl-phenylamine

(4-aminophenyl)(phenyl)methanone

Downstream raw materials:

1-benzyl-4-isocyanatobenzene

p-benzylphenol

1-benzyl-4-iodobenzene

N-[4-(phenylmethyl)phenyl]acetamide

Refernces

• 1、 Dai, Xingchao,He, Dongcheng,Li, Teng,Shi, Feng,Wang, Hongli,Wang, Tao,Wang, Xinzhi. "Efficient hydrogenation catalyst designing via preferential adsorption sites construction towards active copper". . p. 397 - 406. Retrieved 2021/07/21.
• 2、 Tang, Jianting,Lv, Leiyang,Dai, Xi-Jie,Li, Chen-Chen,Li, Lu,Li, Chao-Jun. "Nickel-catalyzed cross-coupling of aldehydes with aryl halides: Via hydrazone intermediates". . p. 1750 - 1753. Retrieved 2018/02/21.