Ethanone, 1-[4-(1-hydroxy-2,2-dimethylpropyl)phenyl]-

Base Information

• Chemical Name: Ethanone, 1-[4-(1-hydroxy-2,2-dimethylpropyl)phenyl]-
• CAS No.: 59480-95-4
• Molecular Formula: C13H18O2
• Molecular Weight: 206.28100
• Mol file: 59480-95-4.mol

Synonyms:1-(p-acetophenyl)-2,2-dimethylpropanol;Ethanone,1-[4-(1-hydroxy-2,2-dimethylpropyl)phenyl];

Chemical Property of Ethanone, 1-[4-(1-hydroxy-2,2-dimethylpropyl)phenyl]-

Chemical Property:

• PSA: 37.30000
• LogP: 2.96870

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[4-(1-hydroxy-2,2-dimethylpropyl)phenyl]-

There total 3 articles about Ethanone, 1-[4-(1-hydroxy-2,2-dimethylpropyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

potassium (1-hydroxy-2,2-dimethylpropyl)trifluoroboranuide (1402010-15-4) + para-bromoacetophenone (99-90-1) → 1-(4-(1-hydroxy-2, 2-dimethylpropyl)phenyl)ethan-1-one (59480-95-4)

Guidance literature:

With dipotassium hydrogenphosphate; nickel(II) bromide dimethoxyethane; Ir(dF(CF₃)ppy)2(bpy)PF₆; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,4-dioxane; at 25 - 27 ℃; for 24h; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.7b02589

Reference yield:

2-methyl-2-(4-[1-hydroxy-2,2-dimethylpropyl]-phenyl)-1,3-dioxolane → 1-(4-(1-hydroxy-2, 2-dimethylpropyl)phenyl)ethan-1-one (59480-95-4)

Guidance literature:

With hydrogenchloride; In chloroform; acetic acid;

Reference yield:

→ 1-(4-(1-hydroxy-2, 2-dimethylpropyl)phenyl)ethan-1-one (59480-95-4)

Guidance literature:

aus dem entspr. Dioxolan;

upstream raw materials:

potassium (1-hydroxy-2,2-dimethylpropyl)trifluoroboranuide

para-bromoacetophenone

Downstream raw materials:

α-methyl-4-(2,2-dimethyl-1-hydroxypropyl)-benzyl alcohol