2-Hydroxypyridine-3-carboxamide

Base Information

• Chemical Name: 2-Hydroxypyridine-3-carboxamide
• CAS No.: 10128-92-4
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933399090
• European Community (EC) Number: 881-529-1
• NSC Number: 87090
• DSSTox Substance ID: DTXSID50293066
• Nikkaji Number: J661.245H
• Wikidata: Q82031640
• Mol file: 10128-92-4.mol

Synonyms:2-Hydroxypyridine-3-carboxamide;2-hydroxynicotinamide;10128-92-4;94083-12-2;2-oxo-1H-pyridine-3-carboxamide;2-oxo-1,2-dihydropyridine-3-carboxamide;3-Pyridinecarboxamide,1,2-dihydro-2-oxo-;3-Pyridinecarboxamide,1,2-dihydro-2-oxo-(9CI);hydroxy nicotinamide;2-Hydroxy-3-pyridinecarboxamide;carbamoyl pyridone;hydroxynicotinamide;NSC87090;SCHEMBL82637;3-pyridinecarboxamide,2-hydroxy-;DTXSID50293066;PQCVYHSKABCYON-UHFFFAOYSA-N;CCG-40551;MFCD18818999;NSC-87090;AKOS006239582;SB53015;BS-33256;CS-0081575;D74336

Chemical Property of 2-Hydroxypyridine-3-carboxamide

Chemical Property:

• Vapor Pressure: 2.89E-11mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 528.7 °C at 760 mmHg
• Flash Point: 273.6 °C
• PSA: 75.95000
• Density: 1.354 g/cm³
• LogP: 0.17410
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 138.042927438
• Heavy Atom Count: 10
• Complexity: 240

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2-dihydro-2-oxo-3-Pyridinecarboxamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC(=O)C(=C1)C(=O)N
• Uses: 2-Hydroxynicotinamide has tuberculostatic activity.

Technology Process of 2-Hydroxypyridine-3-carboxamide

There total 8 articles about 2-Hydroxypyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-acetyl-2-hydroxynicotinamide (101392-31-8) → 1,2-dihydro-2-oxopyridine-3-carboxamide (10128-92-4)

Guidance literature:

With hydrazine; In methanol; for 0.166667h; Ambient temperature;

DOI:10.1002/jhet.5570220332

Reference yield: 87.0%

ethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (27805-12-5) → 1,2-dihydro-2-oxopyridine-3-carboxamide (10128-92-4)

Guidance literature:

With ammonia; In methanol; for 15h; Ambient temperature;

DOI:10.1002/jhet.5570260656

Reference yield: 70.0%

2-chloronicotinamide (10366-35-5) → 2-hydroxynicotinamide (10128-92-4,94083-12-2)

Guidance literature:

With acetylhydroxamic acid; potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.6b00876

upstream raw materials:

2-hydroxy-3-cyanopyridine

2-fluoronicotinamide

piperidine

2-chloronicotinamide

Downstream raw materials:

2-hydroxy-3-carboxypyridine

C₃₂H₂₆N₂O₉

2-chloro-5-nitropyridine-3-carbonitrile

2-chloro-5-nitronicotinamide