2-Fluoronicotinamide

Base Information

• Chemical Name: 2-Fluoronicotinamide
• CAS No.: 364-22-7
• Molecular Formula: C6H5 F N2 O
• Molecular Weight: 140.117
• Hs Code.: 2933399090
• Mol file: 364-22-7.mol

Synonyms:Nicotinamide,2-fluoro- (8CI); 2-Fluoro-3-pyridinecarboxamide; 2-Fluoronicotinamide; NSC74198

Chemical Property of 2-Fluoronicotinamide

Chemical Property:

• Vapor Pressure: 0.00242mmHg at 25°C
• Melting Point: 120.9-122 °C
• Boiling Point: 287.9°Cat760mmHg
• PKA: 14.10±0.50(Predicted)
• Flash Point: 127.9°C
• PSA: 55.98000
• Density: 1.327g/cm³
• LogP: 1.01990
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoronicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoronicotinamide

There total 6 articles about 2-Fluoronicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2-fluoronicotinic acid (393-55-5) → 2-fluoronicotinamide (364-22-7)

Guidance literature:

2-fluoronicotinic acid; With thionyl chloride; for 18h; Heating / reflux;

With ammonia; In benzene; for 21h;

Reference yield:

2-fluoronicotinic acid chloride (119899-26-2) → 2-fluoronicotinamide (364-22-7)

Guidance literature:

With ammonia; benzene;

DOI:10.1021/ja01171a518

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 2-fluoronicotinamide (364-22-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium nitrite; aqueous tetrafluoroboric acid / Diazotization

2: aqueous KMnO₄

3: SOCl₂

4: NH₃; benzene

With potassium permanganate; tetrafluoroboric acid; thionyl chloride; ammonia; sodium nitrite; benzene;

DOI:10.1021/ja01171a518

upstream raw materials:

2-fluoronicotinic acid chloride

methyl 2-fluoro-3-pyridinecarboxylate

2-aminopyridin-3-carboxylic acid

2-fluoronicotinic acid

Downstream raw materials:

2-hydroxynicotinamide

2-hydroxy-3-carboxypyridine

3-cyano-2-fluoropyridine

Refernces