N-Ethyl-p-methoxy-alpha-methylphenethylamine hydrochloride

Base Information

• Chemical Name: N-Ethyl-p-methoxy-alpha-methylphenethylamine hydrochloride
• CAS No.: 93963-24-7
• Molecular Formula: C12H20ClNO
• Molecular Weight: 229.75
• European Community (EC) Number: 300-765-3
• DSSTox Substance ID: DTXSID90916868
• Mol file: 93963-24-7.mol

Synonyms:93963-24-7;N-Ethyl-p-methoxy-alpha-methylphenethylamine hydrochloride;2-Ethylamino-1-(4-methoxyphenyl)propane Hydrochloride;N-ethyl-1-(4-methoxyphenyl)propan-2-amine hydrochloride;N-Ethyl-N-[2-(4-methoxyphenyl)-1-methylethyl]amine hydrochloride;EINECS 300-765-3;N-ethyl-1-(4-methoxyphenyl)propan-2-amine;hydrochloride;ethyl[1-(4-methoxyphenyl)propan-2-yl]amine hydrochloride;4-(2-Ethylaminopropyl)anisole Hydrochloride;Phenethylamine, N-ethyl-p-methoxy-alpha-methyl-, hydrochloride;Benzeneethanamine, N-ethyl-4-methoxy-alpha-methyl-, hydrochloride;N-[(1RS)-1-[(4-Methoxyphenyl)methyl]ethyl]ethanamine Hydrochloride;SCHEMBL4678801;DTXSID90916868;STR05384;AKOS015890648;LS-103491;CS-0325714;E0387;FT-0651602;2-Ethylamino-1-(4-methoxyphenyl)propane HCl;D90500;A844752;J-523574;N-[2-(4-methoxyphenyl)-1-methylethyl]ethylamine hydrochloride;Benzeneethanamine,N-ethyl-4-methoxy-a-methyl-,hydrochloride(1:1);N-Ethyl-1-(4-methoxyphenyl)-2-propanamine hydrochloride, AldrichCPR;Benzeneethanamine, N-ethyl-4-methoxy-alpha-methyl-, hydrochloride (9CI);N-Ethyl-1-(4-methoxyphenyl)propan-2-amine--hydrogen chloride (1/1);PMEA HCl (p-Methoxyethylamphetamine Hydrochloride) 1.0 mg/ml in Methanol (as free base)

Chemical Property of N-Ethyl-p-methoxy-alpha-methylphenethylamine hydrochloride

Chemical Property:

• Melting Point: 156-157 °C
• Boiling Point: 280.6 °C at 760 mmHg
• Flash Point: 116.1 °C
• PSA: 21.26000
• LogP: 3.42860
• Water Solubility.: very faint turbidity in Water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 229.1233420
• Heavy Atom Count: 15
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

2-Ethylamino-1-(4-methoxyphenyl)propane Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC(C)CC1=CC=C(C=C1)OC.Cl
• Description: N-ethyl-4-Methoxyamphetamine (EMA) is an analog of 4-MA (Item No. 12041). The addition of an N-ethyl substituent decreases analgesic potency. Other physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
• Uses: An analogue of the CNS stimulant Amphetamine (A634248) with increased analgesic effects. Controlled Substance.

Technology Process of N-Ethyl-p-methoxy-alpha-methylphenethylamine hydrochloride

There total 1 articles about N-Ethyl-p-methoxy-alpha-methylphenethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxybenzyl methyl ketone (122-84-9) + ethylamine (75-04-7,85404-22-4) → 4-methoxy-N-ethylamphetamine hydrochloride (93963-24-7)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 24h; under 1810.02 Torr;

DOI:10.1080/004982599238344

Reference yield:

4-methoxy-N-ethylamphetamine hydrochloride (93963-24-7) + benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate (10314-99-5) → N-[2-(4-Methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine dihydrochloride hemihydrate + N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-[1-(benzyloxycarbonyl)piperidin-4-ylcarbonyl]amine (241134-39-4)

Guidance literature:

With sodium carbonate; In hexane; water; toluene;

upstream raw materials:

4-methoxybenzyl methyl ketone

ethylamine

Downstream raw materials:

N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-[1-(benzyloxycarbonyl)piperidin-4-ylcarbonyl]amine