3-Cytidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxyadenylyl-(3.5)-N-benzoyl-2-deoxy-, 2-chlorophenyl 2-cyanoethyl ester

Base Information

• Chemical Name: 3-Cytidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxyadenylyl-(3.5)-N-benzoyl-2-deoxy-, 2-chlorophenyl 2-cyanoethyl ester
• CAS No.: 75269-18-0
• Molecular Formula: C₆₉H₆₁Cl₂N₉O₁₆P₂
• Molecular Weight: 1405.15
• Mol file: 75269-18-0.mol

Synonyms:

Chemical Property of 3-Cytidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxyadenylyl-(3.5)-N-benzoyl-2-deoxy-, 2-chlorophenyl 2-cyanoethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Cytidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxyadenylyl-(3.5)-N-benzoyl-2-deoxy-, 2-chlorophenyl 2-cyanoethyl ester

There total 8 articles about 3-Cytidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxyadenylyl-(3.5)-N-benzoyl-2-deoxy-, 2-chlorophenyl 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5'-O-(dimethoxytrityl)-N-benzoyl-2'-deoxyadenosine 3'-(o-chlorophenyl) phosphate triethylammonium salt (85381-22-2) + N4-benzoyl-2'-deoxycytidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate (80817-38-5) → N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester (75269-18-0)

Guidance literature:

With 1-methyl-1H-imidazole; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In pyridine; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4039(00)98833-6

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester (75269-18-0)

Guidance literature:

Multi-step reaction with 4 steps

2: 1-methyl imidazole

3: 2 percent BSA

4: mesitylenesulfonyl-3-nitrotriazolide

With 1-methyl-1H-imidazole; benzenesulfonamide; mesitylenesulfonyl-3-nitrotriazolide;

DOI:10.1248/cpb.34.2202

Reference yield:

[1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (76958-61-7) → N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester (75269-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / pyridine

2: mesitylenesulfonyl-3-nitrotriazolide

With mesitylenesulfonyl-3-nitrotriazolide; water; In pyridine;

DOI:10.1248/cpb.34.2202

upstream raw materials:

5'-O-(dimethoxytrityl)-N-benzoyl-2'-deoxyadenosine 3'-(o-chlorophenyl) phosphate triethylammonium salt

N⁴-benzoyl-2'-deoxycytidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate

N-4-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxycitidine 3'-(o-chlorophenyl β-cyanoethyl phosphate)

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)