2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

Base Information

Chemical Name:2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid
CAS No.:60138-96-7
Molecular Formula:C17H17ClO4
Molecular Weight:320.773
Hs Code.:
DSSTox Substance ID:DTXSID50552468
Wikidata:Q82432740

Synonyms:60138-96-7;DTXSID50552468;2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

Suppliers and Price of 2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:320.0815367
Heavy Atom Count:22
Complexity:370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=C(C(=C1Cl)OC)C)OCC2=CC=CC=C2)C(=O)O

Technology Process of 2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

There total 7 articles about 2-(Benzyloxy)-5-chloro-4-methoxy-3,6-dimethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 111258-53-8
ethyl 2-benzyloxy-5-chloro-4-methoxy-3,6-dimethylbenzoate

: 60138-96-7
2-benzyloxy-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 90 - 100 ℃; for 4.5h;

Reference yield:

: 31581-32-5
ethyl 2,4-dihydroxy-3,6-dimethylbenzoate

: 60138-96-7
2-benzyloxy-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuryl chloride / diethyl ether / 16 h / 25 °C

2: 98 percent / potassium carbonate / acetone / 21 h / Heating

3: 66 percent / boron trichloride / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) RT, 4 h

4: 88 percent / potassium carbonate / acetone / 22 h / Heating

5: 80 percent / potassium hydroxide / dimethylsulfoxide / 4.5 h / 90 - 100 °C

With potassium hydroxide; sulfuryl dichloride; boron trichloride; potassium carbonate; In diethyl ether; dichloromethane; dimethyl sulfoxide; acetone;

Reference yield:

: 57074-25-6
ethyl 3-chloro-4,6-dihydroxy-2,5-dimethylbenzoate

: 60138-96-7
2-benzyloxy-5-chloro-4-methoxy-3,6-dimethylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / potassium carbonate / acetone / 21 h / Heating

2: 66 percent / boron trichloride / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) RT, 4 h

3: 88 percent / potassium carbonate / acetone / 22 h / Heating

4: 80 percent / potassium hydroxide / dimethylsulfoxide / 4.5 h / 90 - 100 °C

With potassium hydroxide; boron trichloride; potassium carbonate; In dichloromethane; dimethyl sulfoxide; acetone;