31581-32-5

Upstream product

• 64-17-5 ethanol 
• 4707-46-4 2,4-dihydroxy-3,6-dimethylbenzoic acid 
• 39503-14-5 ethyl hematommate 
• 56410-29-8 3-bromo-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 4707-47-5 2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester 
• 34883-14-2 2,4-dihydroxy-3,6-dimethylbenzaldehyde 
• 261174-55-4 2-hydroxy-4-(2-hydroxy-4-methoxy-3,6-dimethyl-benzoyloxy)-3,6-dimethyl-benzoic acid ethyl ester 

Downstream Products

• 4707-46-4 2,4-dihydroxy-3,6-dimethylbenzoic acid 
• 148238-89-5 ethyl 3-formyl-4,6-dihydroxy-2,5-dimethylbenzoate 
• 261174-49-6 n-propyl 2,4-dihydroxy-3,6-dimethylbenzoate 
• 261174-55-4 2-hydroxy-4-(2-hydroxy-4-methoxy-3,6-dimethyl-benzoyloxy)-3,6-dimethyl-benzoic acid ethyl ester 
• 261174-51-0 ethyl 2-hydroxy-4-(4-methoxybenzyloxy)-3,6-dimethylbenzoate 
• 261174-50-9 2,4-dihydroxy-3,6-dimethyl-benzoic acid isopropyl ester 
• 56410-30-1 benzyl 2,4-dihydroxy-3,6-dimethylbenzoate 
• 113706-24-4 isopseudocyphellarin A 
• 113689-50-2 2'-O-methylisopseudocyphellarin A 
• 113689-54-6 3-formyl-4,6-dihydroxy-2,5-dimethylbenzoic acid 
• 81050-81-9 3-chloro-4,6-dihydroxy-2,5-dimethylbenzoic acid 
• 111258-53-8 ethyl 2-benzyloxy-5-chloro-4-methoxy-3,6-dimethylbenzoate 
• 60138-96-7 2-benzyloxy-5-chloro-4-methoxy-3,6-dimethylbenzoic acid 
• 159432-88-9 C₆₈H₆₆O₁₄ 

Relevant academic research and scientific papers

Activity-guided isolation of an antiandrogenic compound of Pygeum africanum

Inactivation of the androgen receptor (AR) through androgen ablation and treatment with antiandrogens is a major goal in the therapy for prostate hyperplasia and prostate cancer. Bioactivity-directed fractionation of a selective dichloromethane extract from the stem bark of Pygeum africanum led to the isolation of the antiandrogenic compound atraric acid. Its activity was examined by an androgen receptor responsive reporter gene assay. For lead structure optimization we transformed the natural occurring compound atraric acid into its ethyl, n-propyl and n-butyl esters and their antiandrogenic activities were examined as well. In addition, benzoic acid was isolated. The structures of all compounds were determined and characterized by means of 1H- and 13C-NMR, HR-EI-mass, IR and UV spectroscopy. Georg Thieme Verlag KG Stuttgart.