3-(PIPERIDIN-4-YL)-1H-INDOLE HYDROCHLORIDE

Base Information

• Chemical Name: 3-(PIPERIDIN-4-YL)-1H-INDOLE HYDROCHLORIDE
• CAS No.: 60155-63-7
• Molecular Formula: C13H16N2.ClH
• Molecular Weight: 236.74000
• Hs Code.: 2933990090
• Mol file: 60155-63-7.mol

Synonyms:3-((PIPERIDIN-1-YL)METHYL)-1H-INDOLE;3-Piperidinomethyl-indol;1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine hydrochloride;4-(1H-indol-3-yl)piperidinium chloride;3-piperidin-1-ylmethyl-indole;INDOLE,3-(PIPERIDINOMETHYL);3-(piperidylmethyl)indole;N-Skatylpiperidine;3-(4'-piperidyl)-indole hydrochloride;3-(piperidin-4-yl)-1H-indole hydrochloride;3-(Piperidinomethyl) indole;3-(piperidin-1-ylmethyl)-phenylboronic acid pinacol ester hydrochloride;3-(4'-Piperidyl)-indol-Hydrochlorid;

Chemical Property of 3-(PIPERIDIN-4-YL)-1H-INDOLE HYDROCHLORIDE

Chemical Property:

• PSA: 27.82000
• LogP: 3.76570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

3-(Piperidin-4-yl)-1H-indolehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(PIPERIDIN-4-YL)-1H-INDOLE HYDROCHLORIDE

There total 9 articles about 3-(PIPERIDIN-4-YL)-1H-INDOLE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert.butyl 4-(1H-indol-3-yl)-piperidine-1-carboxylate (155302-28-6) → 4-(1H-indol-3-yl)piperidinium chloride (60155-63-7,74163-75-0)

Guidance literature:

Reference yield: 69.0%

3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (65347-55-9) → 4-(1H-indol-3-yl)piperidinium chloride (60155-63-7,74163-75-0)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; for 3h;

DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(1H-indol-3-yl)piperidinium chloride (60155-63-7,74163-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 1 h / 20 °C

1.2: 24 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.2: 0.5 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2013.09.096

upstream raw materials:

tert.butyl 4-(1H-indol-3-yl)-piperidine-1-carboxylate

indole

piperidine-4,4-diol hydrochloride

3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Downstream raw materials:

4-(1H-indol-3-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

Refernces

• 1、 Yang, Shyh-Ming,Tang, Yuting,Zhang, Rui,Lu, Huajun,Kuo, Gee-Hong,Gaul, Michael D.,Li, Yaxin,Ho, George,Conway, James G.,Liang, Yin,Lenhard, James M.,Demarest, Keith T.,Murray, William V.. "4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs". supporting information. p. 6773 - 6776. Retrieved 2014/01/06.
• 2、 -. "INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES". Page/Page column 201. . Retrieved 2010/12/29.