4-Benzyl-7,7-diphenyl-1,4-oxazepane hydrochloride

Base Information

• Chemical Name: 4-Benzyl-7,7-diphenyl-1,4-oxazepane hydrochloride
• CAS No.: 60162-87-0
• Molecular Formula: C24H25NO.ClH
• Molecular Weight: 379.92200
• Hs Code.: 2934999090
• Mol file: 60162-87-0.mol

Synonyms:4-Benzyl-7,7-diphenyl-1,4-oxazepane hydrochloride;4-benzyl-7,7-diphenyl-hexahydro-1,4-oxazepine hydrochloride;

Chemical Property of 4-Benzyl-7,7-diphenyl-1,4-oxazepane hydrochloride

Chemical Property:

• PSA: 12.47000
• LogP: 5.59260

Purity/Quality:

99% ^*data from raw suppliers

4-Benzyl-7,7-diphenyl-1,4-oxazepanehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyl-7,7-diphenyl-1,4-oxazepane hydrochloride

There total 8 articles about 4-Benzyl-7,7-diphenyl-1,4-oxazepane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyl-7,7-diphenyl-[1,4]oxazepan-3-one (60163-53-3) → 4-benzyl-7,7-diphenyl-hexahydro-1,4-oxazepine hydrochloride (60162-87-0)

Guidance literature:

With sodium hydroxide; In diethyl ether; dichloromethane; water; acetone;

Reference yield:

3-hydroxy-3,3-diphenylpropanenitrile (3531-23-5) → 4-benzyl-7,7-diphenyl-hexahydro-1,4-oxazepine hydrochloride (60162-87-0)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydroxide / diethyl ether; dichloromethane; water

2: pyridine; sodium hydroxide / dichloromethane; water

3: sodium hydroxide / diethyl ether; chloroform; water

4: dichloromethane; N-ethyl-N,N-diisopropylamine

5: N-methyl-acetamide

6: sodium hydroxide / diethyl ether; dichloromethane; water; acetone

With pyridine; sodium hydroxide; In N-methyl-acetamide; diethyl ether; dichloromethane; chloroform; water; N-ethyl-N,N-diisopropylamine; acetone;

Reference yield:

3-benzylamino-1,1-diphenyl-propan-1-ol (60163-40-8) → 4-benzyl-7,7-diphenyl-hexahydro-1,4-oxazepine hydrochloride (60162-87-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane; N-ethyl-N,N-diisopropylamine

2: N-methyl-acetamide

3: sodium hydroxide / diethyl ether; dichloromethane; water; acetone

With sodium hydroxide; In N-methyl-acetamide; diethyl ether; dichloromethane; water; N-ethyl-N,N-diisopropylamine; acetone;

upstream raw materials:

4-benzyl-7,7-diphenyl-[1,4]oxazepan-3-one

3-hydroxy-3,3-diphenylpropanenitrile

3-benzylamino-1,1-diphenyl-propan-1-ol

N-(3-hydroxy-3,3-diphenyl-propyl)-benzamide

Downstream raw materials:

7,7-diphenyl-hexahydro-1,4-oxazepine cyclamate