3531-23-5Relevant academic research and scientific papers
Solvent-free method for preparing diphenyl hydroxypropanitrile
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Paragraph 0010; 0016; 0017; 0019; 0020; 0022, (2018/11/04)
The invention discloses a method for preparing 3, 3-diphenyl-3-hydroxypropanitrile. According to the method, samarium metal facilitates diphenyl ketone and acetonitrile to perform coupled reaction under catalyzing of cuprous iodide without solvent to prep
Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound
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Paragraph 0234-0236, (2020/09/17)
Provided is an easy method (coupling method) capable of easily synthesizing a compound group in which aromatic molecules and aromatic molecules are coupled, a compound group in which aromatic molecules and alkene molecules are coupled, and the like without producing halogen waste and without the need to use scarce and expensive palladium. A compound (A) shown by general formula (A): Ar-H and a compound (B1) shown by general formula (B1): RaOCO-Ar', a compound (B2) shown by general formula (B2): RbCH=C(Ar")2, or a compound (B3) shown by general formula (B3): RcOCOCH=C(Ar")2 are reacted in the presence of a nickel compound.
Conversion of 3,3,3-Trisubstituted Prop-1-ynes with tert-Butylhydrazine into 3,3,3-Trisubstituted Propionitriles Catalyzed by TpRh(C2H4)2/P(2-furyl)3
Fukumoto, Yoshiya,Tamura, Yuto,Iyori, Yasuaki,Chatani, Naoto
, p. 3161 - 3167 (2016/05/19)
The combination of TpRh(C2H4)2 (Tp = tris(pyrazol-1-yl)borate) and P(2-furyl)3 catalyzes the reaction of tertiary alkyl-substituted alkynes with tert-butylhydrazine, leading to the formation of 3,3,3-trisubstituted propionitrile derivatives. This reaction system is applicable to 1,1-disubstituted propargyl alcohols and amines to afford the corresponding β-cyanohydrins and β-amino nitriles, respectively. The catalytic cycle involves the formation of a vinylidenerhodium complex as a key intermediate.
C-H alkenylation of azoles with enols and esters by nickel catalysis
Meng, Lingkui,Kamada, Yuko,Muto, Kei,Yamaguchi, Junichiro,Itami, Kenichiro
supporting information, p. 10048 - 10051 (2013/10/01)
Rather u(Ni)que: Two new C-H alkenylation reactions, that is C-H/Ci￡O alkenylation and decarbonylative C-H alkenylation, of azoles are uniquely catalyzed by Ni/dcype. These azole alkenylation reactions are successfully applied to the convergent formal synthesis of siphonazoleB.
Novel process for the synthesis of class I antiarrhythmic agent (±)-cibenzoline and its analogs
Gholap, Atul R.,Paul, Vincent,Srinivasan, Kumar V.
, p. 2967 - 2982 (2008/12/22)
Synthesis of (±)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from β-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2- diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (±)-2-(2,2-diphenylcyclopropyl)- 2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields. Copyright Taylor & Francis Group, LLC.
Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile
Kawano, Yoshikazu,Kaneko, Nobuya,Mukaiyama, Teruaki
, p. 1508 - 1509 (2007/10/03)
Catalytic cyanomethylation of various carbonyl compounds with (trimethylsilyl)acetonitrile (TMSCH2CN) in the presence of Lewis bases such as cesium or lithium acetate proceeded smoothly to afford the corresponding cyanomethylated adducts in good yields. Copyright
Role of water and phase transfer catalysts in the kinetics of condensation of diaryl ketones with acetonitrile initiated by solid potassium hydroxide
Bentley, T. William,Jones, Ray V. H.,Larder, Annette H.,Lock, Stephen J.
, p. 89 - 94 (2007/10/03)
The kinetics of reactions of benzophenone and substituted derivatives with acetonitrile in the presence of excess solid potassium hydroxide (KOH) to give 2,2-diarylacrylonitriles are reported. Reaction rates are strongly temperature dependent, and water,
Cerium (III) chloride mediated nitrile aldol reactions: Enhanced diastereoselectivities using a chiral organocerium complex
Xiao, Zejun,Timberlake, Jack W.
, p. 4211 - 4222 (2007/10/03)
The addition of anhydrous cerium chloride to nitrile aldol reactions has been found to provide high yields of [β-hydroxynitriles. Also, the aldol reaction of α, β-unsaturated carbonyl compounds with nitrile enolates in the presence of cerium chloride affo
Novel Reaction of Dibutyl(cyanomethyl)telluronium Chloride with Carbonyl Compounds Mediated by Organolithium Reagents: Highly Efficient Synthesis of β-Hydroxy Nitriles
Zhou, Zhang-Lin,Shi, Lin-Lan,Huang, Yao-Zeng
, p. 1931 - 1933 (2007/10/02)
Dibutyl(cyanomethyl)telluronium chloride, a precursor of stabilized telluronium ylides, after being treated with organolithium reagents reacted with carbonyl compounds to afford β-hydroxy nitriles instead of α,β-unsaturated nitriles in excellent yields.
1,4-Oxazepines
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, (2008/06/13)
7,7-Diphenyl-hexahydro-1,4-oxazepines, e.g. those of the formula: STR1 acyl derivatives, N-oxides and salts thereof are antidepressants.
