1,3-Bis(bromomethyl)-2-methoxy-5-methylbenzene

Base Information

• Chemical Name: 1,3-Bis(bromomethyl)-2-methoxy-5-methylbenzene
• CAS No.: 60232-82-8
• Molecular Formula: C10H12Br2O
• Molecular Weight: 308.013
• European Community (EC) Number: 684-615-5
• DSSTox Substance ID: DTXSID70404854
• Nikkaji Number: J1.221.480D
• Wikidata: Q82209192
• Mol file: 60232-82-8.mol

Synonyms:1,3-bis(bromomethyl)-2-methoxy-5-methylbenzene;60232-82-8;SCHEMBL2811660;DTXSID70404854;WWFFUXQAXQXEJR-UHFFFAOYSA-N;2,6-bis bromomethyl-4-methylanisole;AKOS024330559

Chemical Property of 1,3-Bis(bromomethyl)-2-methoxy-5-methylbenzene

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 307.92344
• Heavy Atom Count: 13
• Complexity: 138

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)CBr)OC)CBr

Technology Process of 1,3-Bis(bromomethyl)-2-methoxy-5-methylbenzene

There total 5 articles about 1,3-Bis(bromomethyl)-2-methoxy-5-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-bis(hydroxymethyl)-4-methyl-anisole (6327-85-1) → 2,6-bis bromomethyl-4-methylanisole (60232-82-8)

Guidance literature:

With phosphorus tribromide;

DOI:10.1016/j.tet.2007.03.007 DOI:10.1002/jhet.5570440636

Reference yield:

2,6-bis(hydroxymethyl)-4-methylphenol (91-04-3) → 2,6-bis bromomethyl-4-methylanisole (60232-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

2: 100 percent / PBr₃

With sodium hydroxide; phosphorus tribromide;

DOI:10.1016/j.tet.2007.03.007

Reference yield:

p-cresol (106-44-5) → 2,6-bis bromomethyl-4-methylanisole (60232-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. K₂CO₃

2: K₂CO₃

3: SOBr₂

With sulfurous dibromide; potassium carbonate;

DOI:10.1021/ja00507a021

upstream raw materials:

2,6-bis(hydroxymethyl)-4-methyl-anisole

2,6-bis(hydroxymethyl)-4-methylphenol

p-cresol

Downstream raw materials:

2-[3-(2-Hydroxy-ethylsulfanylmethyl)-2-methoxy-5-methyl-benzylsulfanyl]-ethanol

2-methoxy-5-methyl-1,3-bis-[3-(trimethylsilanyl)prop-2-ynyl]benzene

C₄₀H₄₂O₁₁S₂

2-methoxy-5-methyl-1,3-bis(2-formylphenoxymethyl)benzene