7-chloroquinazoline-2,4(1H,3H)-dione

Base Information

• Chemical Name: 7-chloroquinazoline-2,4(1H,3H)-dione
• CAS No.: 13165-35-0
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.593
• Hs Code.: 2933990090
• Mol file: 13165-35-0.mol

Synonyms:7-Chloro-2,4(1H,3H)-quinazolinedione;7-Chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline;NSC 60434;

Chemical Property of 7-chloroquinazoline-2,4(1H,3H)-dione

Chemical Property:

• Melting Point: 360-362℃
• Refractive Index: 1.601
• PKA: 10.13±0.20(Predicted)
• PSA: 66.24000
• Density: 1.475g/cm³
• LogP: 1.69440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

7-Chloroquinazoline-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-chloroquinazoline-2,4(1H,3H)-dione

There total 16 articles about 7-chloroquinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

urea (57-13-6) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 7-chloroquinazoline-2,4-dione (13165-35-0)

Guidance literature:

at 200 ℃; for 1h;

Reference yield: 98.0%

carbon dioxide (124-38-9,18923-20-1) + 2-amino-4-chlorobenzonitrile (38487-86-4) → 7-chloroquinazoline-2,4-dione (13165-35-0)

Guidance literature:

With Zhabuye basic salt-lake brine; at 140 ℃; for 30h; under 7500.75 Torr; Sealed tube;

DOI:10.1002/cssc.201802431

Reference yield: 98.0%

→ 7-chloroquinazoline-2,4-dione (13165-35-0)

Guidance literature:

at 220 ℃; for 4h;

upstream raw materials:

4-chloro-2-ureido-benzoic acid

urea

2-Amino-4-chlorobenzoic acid

2-amino-4-chloro-benzoic acid methyl ester

Downstream raw materials:

2,4,7-trichloroquinazoline

7-chloro-6-nitro-2,4(1H,3H)-quinazolinedione

1-(3,5-di-O-p-toluoyl-2-deoxy-α,β-D-erythro-pentofuranosyl)-7-chloro-quinazoline-2,4(3H)-dione

2-((2,7-dichloro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

Refernces

• 1、 Rasal, Kalidas B.,Yadav, Ganapati D.. "Carbon Dioxide Mediated Novel Synthesis of Quinazoline-2,4(1H,3H)-dione in Water". . p. 2067 - 2073. Retrieved 2016.
• 2、 Lang, Xian-Dong,Zhang, Shuai,Song, Qing-Wen,He, Liang-Nian. "Tetra-butylphosphonium arginine-based ionic liquid-promoted cyclization of 2-aminobenzonitrile with carbon dioxide". . p. 15668 - 15673. Retrieved 2015.
• 3、 Mizuno, Takumi,Mihara, Masatoshi,Nakai, Takeo,Iwai, Toshiyuki,Ito, Takatoshi. "Solvent-free synthesis of quinazoline-2,4(1H,3H)-diones using carbon dioxide and a catalytic amount of DBU". . p. 2524 - 2528. Retrieved 2007.
• 4、 Mizuno, Takumi,Ishino, Yoshio. "Highly efficient synthesis of 1H-quinazoline-2,4-diones using carbon dioxide in the presence of catalytic amount of DBU". . p. 3155 - 3158. Retrieved 2002.
• 5、 Hu, Jiayin,Chen, Shangqing,Guo, Yafei,Li, Long,Deng, Tianlong. "Basic Salt-Lake Brine: An Efficient Catalyst for the Transformation of CO2 into Quinazoline-2,4(1 H,3 H)-diones". . p. 4219 - 4225. Retrieved 2018.
• 6、 Kimura, Toshihiro,Sunaba, Hanako,Kamata, Keigo,Mizuno, Noritaka. "Efficient [WO4]2--catalyzed chemical fixation of carbon dioxide with 2-aminobenzonitriles to quinazoline-2,4(1 H,3 H)-diones". . p. 13001 - 13008. Retrieved 2012.
• 7、 Zhao, Guo-Ying,Mu, Ling-Ling,Ullah, Latif,Wang, Meng,Li, Hong-Ping,Guan, Xin-Xin. "CO2 involved synthesis of quinazoline-2,4(1 H,3 H)-diones in water using melamine as a thermoregulated catalyst". . p. 212 - 218. Retrieved 2019.
• 8、 Wang, Qianyu,Lu, Chengrong,Zhao, Bei,Yao, Yingming. "Synthesis and Characterization of Amidato Divalent Lanthanide Complexes and Their Use in Forming 2,4-Quinazolidinones from CO2 and 2-Aminobenzonitriles". . p. 2555 - 2559. Retrieved 2016.
• 9、 Tian, Xin-Chuan,Huang, Xing,Wang, Dan,Gao, Feng. "Eco-efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones at room temperature in water". . p. 824 - 829. Retrieved 2014.
• 10、 Mizuno, Takumi,Iwai, Toshiyuki,Ishino, Yoshio. "The simple solvent-free synthesis of 1H-quinazoline-2,4-diones using supercritical carbon dioxide and catalytic amount of base". . p. 7073 - 7075. Retrieved 2004.