Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)-

Base Information

Chemical Name:Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)-
CAS No.:60285-09-8
Molecular Formula:C14H17ClFNO
Molecular Weight:269.746
Hs Code.:
DSSTox Substance ID:DTXSID70441168
Wikidata:Q82257804

Synonyms:60285-09-8;Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)-;1-(2-chloroethyl)-4-(4-fluorobenzoyl)piperidine;SCHEMBL7328197;DTXSID70441168;UJQXEDGDZCOECV-UHFFFAOYSA-N

Suppliers and Price of Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)-

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:269.0982700
Heavy Atom Count:18
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCCl

Technology Process of Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)-

There total 4 articles about Methanone, [1-(2-chloroethyl)-4-piperidinyl](4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 106088-85-1
4-(4-fluorobenzoyl)-1-(2-hydroxyethyl)piperidine

: 60285-09-8
1-(2-chloroethyl)-4-(4-fluorobenzoyl)piperidine

Guidance literature:: With tetrachloromethane; triphenylphosphine; In pyridine; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(99)00311-9

Reference yield: 65.0%

: 25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride

: 540-51-2
2-bromoethanol

: 60285-09-8
1-(2-chloroethyl)-4-(4-fluorobenzoyl)piperidine

Guidance literature:: With hydrogenchloride; thionyl chloride; In chloroform;

Reference yield:

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 60285-09-8
1-(2-chloroethyl)-4-(4-fluorobenzoyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / NaOH / ethanol / 2 h / Heating

2: 77 percent / CCl₄; Ph₃P / pyridine / 1 h / 20 °C

With tetrachloromethane; sodium hydroxide; triphenylphosphine; In pyridine; ethanol; 1: Alkylation / 2: Substitution;
DOI:10.1016/S0968-0896(99)00311-9