(R)-2-(1-methylpyrrolidin-2-yl)ethanol

Base Information

• Chemical Name: (R)-2-(1-methylpyrrolidin-2-yl)ethanol
• CAS No.: 60307-26-8
• Molecular Formula: C7H15NO
• Molecular Weight: 129.20000
• UNII: 2K70C7O5V0
• DSSTox Substance ID: DTXSID101298451
• Wikidata: Q27254864
• Mol file: 60307-26-8.mol

Synonyms:60307-26-8;(R)-2-(1-methylpyrrolidin-2-yl)ethanol;(R)-2-(1-Methyl-pyrrolidin-2-yl)-ethanol;2-[(2R)-1-methylpyrrolidin-2-yl]ethanol;2K70C7O5V0;1-Methyl-2-pyrrolidineethanol, (+)-;1-Methyl-2-pyrrolidineethanol, (2R)-;D-1-methyl-2-(hydroxyethyl)pyrrolidine;2-Pyrrolidineethanol, 1-methyl-, (2R)-;(2R)-1-METHYL-2-PYRROLIDINEETHANOL;2-[(2R)-1-methylpyrrolidin-2-yl]ethan-1-ol;UNII-2K70C7O5V0;SCHEMBL4065310;FYVMBPXFPFAECB-SSDOTTSWSA-N;DTXSID101298451;MFCD18914398;AKOS025290406;TS-01700;(r)-2-(1-methylpyrrolidine-2-yl)ethanol;CS-0341913;A869007;Q27254864

Chemical Property of (R)-2-(1-methylpyrrolidin-2-yl)ethanol

Chemical Property:

• PSA: 23.47000
• LogP: 0.40090
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(1-Methylpyrrolidin-2-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1CCO
• Isomeric SMILES: CN1CCC[C@@H]1CCO

Technology Process of (R)-2-(1-methylpyrrolidin-2-yl)ethanol

There total 9 articles about (R)-2-(1-methylpyrrolidin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (101555-60-6) → R(+)-1-methyl-2-(2-hydroxyethyl)pyrrolidine (60307-26-8)

Guidance literature:

2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester; With lithium aluminium tetrahydride; In 1,4-dioxane; at 0 - 70 ℃; Reflux;

With water; In 1,4-dioxane; at 0 ℃;

Reference yield: 73.0%

(R)-ethyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate → R(+)-1-methyl-2-(2-hydroxyethyl)pyrrolidine (60307-26-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Reflux;

DOI:10.1007/s12272-015-0641-4

Reference yield: 48.7%

2-(1-methyl-2-pyrrolidine)ethanol (67004-64-2) → R(+)-1-methyl-2-(2-hydroxyethyl)pyrrolidine (60307-26-8)

Guidance literature:

With malic acid; In methanol; at 45 - 50 ℃; for 1h; Reagent/catalyst; Solvent;

upstream raw materials:

((R)-1-Formyl-pyrrolidin-2-yl)-acetic acid ethyl ester

(R)-Pyrrolidin-2-yl-acetic acid ethyl ester

1-<1'-(S)-phenylethyl>-2-(ethoxycarbonylmethylidene)pyrrolidine

[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester

Downstream raw materials:

(+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride