(+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

Base Information

• Chemical Name: (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride
• CAS No.: 67499-71-2
• Molecular Formula: C₇H₁₄ClN*ClH
• Molecular Weight: 184.109
• Mol file: 67499-71-2.mol

Synonyms:(+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

Chemical Property of (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

Chemical Property:

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

There total 4 articles about (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

R(+)-1-methyl-2-(2-hydroxyethyl)pyrrolidine (60307-26-8) → (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (67499-71-2,56824-22-7)

Guidance literature:

With thionyl chloride; In chloroform; at 0 ℃; for 1h; Reflux;

DOI:10.1007/s12272-015-0641-4

Reference yield:

(S)-ethyl 2-(2-hydroxyethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate (1352748-96-9) → (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (67499-71-2,56824-22-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

3: thionyl chloride / chloroform / 1 h / 0 °C / Reflux

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; palladium; In tetrahydrofuran; chloroform;

DOI:10.1007/s12272-015-0641-4

Reference yield:

(R)-ethyl 2-(2-hydroxyethyl)pyrrolidine-1-carboxylate → (+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride (67499-71-2,56824-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

2: thionyl chloride / chloroform / 1 h / 0 °C / Reflux

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; chloroform;

DOI:10.1007/s12272-015-0641-4

upstream raw materials:

R(+)-1-methyl-2-(2-hydroxyethyl)pyrrolidine

(S)-ethyl 2-(2-hydroxyethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate

2-(1-methyl-2-pyrrolidine)ethanol

Downstream raw materials:

(R)-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine