(1-Hydroxycyclohexyl)phenylphosphinic chloride

Base Information

• Chemical Name: (1-Hydroxycyclohexyl)phenylphosphinic chloride
• CAS No.: 60340-72-9
• Molecular Formula: C12H16ClO2P
• Molecular Weight: 258.685
• DSSTox Substance ID: DTXSID40505807
• Mol file: 60340-72-9.mol

Synonyms:60340-72-9;(1-Hydroxycyclohexyl)phenylphosphinic chloride;DTXSID40505807;phenyl-alpha-hydroxycyclohexylphosphinyl chloride

Chemical Property of (1-Hydroxycyclohexyl)phenylphosphinic chloride

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 258.0576444
• Heavy Atom Count: 16
• Complexity: 281

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)(O)P(=O)(C2=CC=CC=C2)Cl

Technology Process of (1-Hydroxycyclohexyl)phenylphosphinic chloride

There total 3 articles about (1-Hydroxycyclohexyl)phenylphosphinic chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl phenylphosphonochloridothioite (23588-02-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → chloroanhydride of phenyl-α-hydroxycyclohexylphosphinic acid (60340-72-9) + phenylphosphinic acid (1779-48-2) + (phenyl)phosphinic chloride (67176-71-0) + Dichlorophenylphosphine (644-97-3)

Guidance literature:

With acetic acid; at 0 ℃; for 240h;

DOI:10.1007/BF00954671

Reference yield:

phenylphosphonous acid (121-70-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + Dichlorophenylphosphine (644-97-3) → chloroanhydride of phenyl-α-hydroxycyclohexylphosphinic acid (60340-72-9)

Guidance literature:

In propionic acid; at -10 ℃;

Reference yield:

→ chloroanhydride of phenyl-α-hydroxycyclohexylphosphinic acid (60340-72-9)

Guidance literature:

C6H5PCl2, Cyclohexanon, H2O;

DOI:10.1007/BF00973428

upstream raw materials:

ethyl phenylphosphonochloridothioite

cyclohexanone

phenylphosphonous acid

Dichlorophenylphosphine