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1779-48-2

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1779-48-2 Usage

Chemical Properties

white crystals or crystalline powder

Uses

Different sources of media describe the Uses of 1779-48-2 differently. You can refer to the following data:
1. Antioxidant, intermediate for metallic-salt formation, accelerator for organic peroxide catalysts.
2. Coproporphyrin I-15N4 is an intermediate in the synthesis of Coproporphyrin I-15N4 Sodium BIsulfate Salt (C685402). Labelled Coproporphyrin I. Coproporphyrin I is a porphyrin, a naturally occuring aromatic heterocyclic marcomolecule. The ratio of Coproporphyrin I and Coproporphyrin III provides a useful biochemical marker for distinguishing familial and sporadic porphyria cutanea tarda. Coproporphyrin I also serve as a biomarker of environmental toxicity and susceptibility in autism.

General Description

Phenylphosphinic acid is also known as phenylphosphonous acid. Kinetics of oxidation of phenylphosphinic acid by metal and non metal oxidants was investigated in a study.2

Purification Methods

Crystallise it from H2O (solubility is 7.7% at 25o). Also purify it by placing the solid in a flask covered with dry Et2O, and allowed it to stand for 1day with intermittent shaking. Et2O is decanted off and the process repeated. After filtration, excess Et2O is removed in a vacuum. It has also been recrystallised from *C6H6. [Michaelis Justus Liebigs Ann Chem 181 265 1876, Banks & Skoog Anal Chem 29 109 1957, NMR: Van Wazer et al. J Am Chem Soc 78 5715 1956, Beilstein 16 IV 1033.]

Check Digit Verification of cas no

The CAS Registry Mumber 1779-48-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,7 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1779-48:
(6*1)+(5*7)+(4*7)+(3*9)+(2*4)+(1*8)=112
112 % 10 = 2
So 1779-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H7O2P/c7-9(8)6-4-2-1-3-5-6/h1-5,9H,(H,7,8)

1779-48-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A17453)  Phenylphosphinic acid, 98%   

  • 1779-48-2

  • 100g

  • 393.0CNY

  • Detail
  • Alfa Aesar

  • (A17453)  Phenylphosphinic acid, 98%   

  • 1779-48-2

  • 500g

  • 1043.0CNY

  • Detail
  • Aldrich

  • (P28808)  Phenylphosphinicacid  99%

  • 1779-48-2

  • P28808-100G

  • 332.28CNY

  • Detail
  • Aldrich

  • (P28808)  Phenylphosphinicacid  99%

  • 1779-48-2

  • P28808-500G

  • 1,010.88CNY

  • Detail

1779-48-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Phenylphosphinic acid

1.2 Other means of identification

Product number -
Other names Phosphonousacid,phenyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Process regulators,Processing aids, not otherwise listed
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1779-48-2 SDS

1779-48-2Relevant articles and documents

-

Sen Gupta

, p. 590 (1970)

-

Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors

Németh, Gábor,Greff, Zoltán,Sipos, Anna,Varga, Zoltán,Székely, Rita,Sebestyén, Mónika,Jászay, Zsuzsa,Béni, Szabolcs,Nemes, Zoltán,Pirat, Jean-Luc,Volle, Jean-No?l,Virieux, David,Gyuris, ágnes,Kelemenics, Katalin,áy, éva,Minarovits, Janos,Szathmary, Susan,Kéri, Gy?rgy,Orfi, László

, p. 3939 - 3965 (2014/06/09)

Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase so far. The aim of this research was to develop novel and selective phosphorus containing CDK9/CycT1 inhibitors. Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized. Prepared compounds were evaluated in an enzymatic CDK9/CycT1 assay. The most potent molecules were tested in cell-based toxicity and HIV proliferation assays. Selectivity of shortlisted compounds against CDKs and other kinases was tested. The best compound was shown to be a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.

Revisited synthesis of aryl-H-phosphinates

Volle, Jean-Noel,Filippini, Damien,Midrier, Camille,Sobecki, Michal,Drag, Marcin,Virieux, David,Pirat, Jean-Luc

body text, p. 2490 - 2494 (2011/09/20)

A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petnehazy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via direct addition of triethyl phosphite to the appropriate Grignard reagent. Subsequent hydrolysis of the phosphonites under acidic conditions gives various aryl-H-phosphinates in high yields and purities. Georg Thieme Verlag Stuttgart, New York.

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