5-Pyrimidinecarboxamide, 2-[4-(diphenylacetyl)-1-piperazinyl]-N-hydroxy-

Base Information

Chemical Name:5-Pyrimidinecarboxamide, 2-[4-(diphenylacetyl)-1-piperazinyl]-N-hydroxy-
CAS No.:603991-95-3
Molecular Formula:C23H23N5O3
Molecular Weight:417.467
Hs Code.:

Synonyms:

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Chemical Property of 5-Pyrimidinecarboxamide, 2-[4-(diphenylacetyl)-1-piperazinyl]-N-hydroxy-

Chemical Property:

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Technology Process of 5-Pyrimidinecarboxamide, 2-[4-(diphenylacetyl)-1-piperazinyl]-N-hydroxy-

There total 5 articles about 5-Pyrimidinecarboxamide, 2-[4-(diphenylacetyl)-1-piperazinyl]-N-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₁N₅O₄

: 603991-95-3
C₂₃H₂₃N₅O₃

Guidance literature:: With acetic acid; trifluoroacetic acid; In methanol; at 20 ℃; for 20h;

Reference yield:

: 603965-77-1
ethyl 2-(piperazin-1-yl) pyrimidine-5-carboxylate

: 603991-95-3
C₂₃H₂₃N₅O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dichloromethane / 24 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol / 72 h / 20 °C

3.1: dmap; diisopropyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 4.25 h / 20 °C

3.2: 4 h

3.3: methylisothiocyanate polystyrene HL (200-400 mesh), 2percent divinylbenzene / 24 h

4.1: trifluoroacetic acid; acetic acid / methanol / 20 h / 20 °C

With dmap; potassium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 148550-51-0
ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

: 603991-95-3
C₂₃H₂₃N₅O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 0.75 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 50 °C

3.1: potassium carbonate / dichloromethane / 24 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 72 h / 20 °C

5.1: dmap; diisopropyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 4.25 h / 20 °C

5.2: 4 h

5.3: methylisothiocyanate polystyrene HL (200-400 mesh), 2percent divinylbenzene / 24 h

6.1: trifluoroacetic acid; acetic acid / methanol / 20 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;