603965-77-1Relevant articles and documents
Compound for inducing BCR-ABL protein degradation through targeted ubiquitination and application thereof
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Paragraph 0035-0037, (2022/03/16)
The invention provides a compound for inducing BCR-ABL protein degradation through targeted ubiquitination. The compound has the advantages that the compound not only has excellent BCR-ABL protein degradation effect and anti-tumor activity, but also has small toxic and side effects on human bodies, and can be used for preparing anti-tumor drugs.
METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS
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, (2022/01/04)
The present disclosure relates to compositions and methods for the treatment of diseases or disorders (e.g., cancer) with bi-steric inhibitors of mTOR in combination with RAS inhibitors. Specifically, in some embodiments this disclosure includes compositions and methods for inducing apoptosis of tumor cells and/or for delaying, preventing, or treating acquired resistance to RAS inhibitors using bi-steric mTOR inhibitors.
MDM2-HDAC double-target inhibitor, medicinal composition and preparation and application of MDM2-HDAC double-target inhibitor
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, (2018/12/14)
The invention provides a MDM2-HDAC double-target inhibitor, a medicinal composition and preparation and application of the MDM2-HDAC double-target inhibitor. The MDM2-HDAC double-target inhibitor hasa structure as shown in formula I. The inhibitor with th